Open Access

HPV16 E6 upregulates Aurora A expression

  • Authors:
    • Yi Guo
    • Jiaming Ma
    • Yahong Zheng
    • Lu Li
    • Xiaowei Gui
    • Qian Wang
    • Xiangkai Meng
    • Hong Shang
  • View Affiliations

  • Published online on: June 27, 2016     https://doi.org/10.3892/ol.2016.4786
  • Pages: 1387-1393
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Overexpression of Aurora A kinase occurs in certain types of cancer, and therefore results in chromosome instability and phosphorylation‑mediated ubiquitylation and degradation of p53 for tumorigenesis. The high-risk subtype human papillomavirus (HPV)16 early oncoprotein E6 is a major contributor inducing host cell immortalization and transformation through interaction with a number of cellular factors. In the present study, co‑immunoprecipitation, glutathione S-transferase pull‑down and immunostaining were used to show that HPV16 E6 and Aurora A bind to each other in vivo and in vitro. Western blotting and reverse transcription‑polymerase chain reaction were used to reveal that HPV16 E6 inhibited cell apoptosis by stabilizing Aurora A expression. The present study may report a new mechanism for the involvement of HPV16 E6 in carcinogenesis, as HPV16 E6 elevates Aurora A expression and the latter may be a common target for oncogenic viruses that result in cell carcinogenesis.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Guo Y, Ma J, Zheng Y, Li L, Gui X, Wang Q, Meng X and Shang H: HPV16 E6 upregulates Aurora A expression. Oncol Lett 12: 1387-1393, 2016
APA
Guo, Y., Ma, J., Zheng, Y., Li, L., Gui, X., Wang, Q. ... Shang, H. (2016). HPV16 E6 upregulates Aurora A expression. Oncology Letters, 12, 1387-1393. https://doi.org/10.3892/ol.2016.4786
MLA
Guo, Y., Ma, J., Zheng, Y., Li, L., Gui, X., Wang, Q., Meng, X., Shang, H."HPV16 E6 upregulates Aurora A expression". Oncology Letters 12.2 (2016): 1387-1393.
Chicago
Guo, Y., Ma, J., Zheng, Y., Li, L., Gui, X., Wang, Q., Meng, X., Shang, H."HPV16 E6 upregulates Aurora A expression". Oncology Letters 12, no. 2 (2016): 1387-1393. https://doi.org/10.3892/ol.2016.4786