Role of periostin in esophageal, gastric and colon cancer (Review)

  • Authors:
    • Tadeusz Moniuszko
    • Andrzej Wincewicz
    • Mariusz Koda
    • Izabela Domysławska
    • Stanisław Sulkowski
  • View Affiliations

  • Published online on: June 9, 2016     https://doi.org/10.3892/ol.2016.4692
  • Pages: 783-787
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Abstract

Periostin, also known as osteoblast-specific factor 2, is a cell‑adhesion protein with pleiotropic properties. The protein serves a vital role in the maintenance and development of tooth and bone tissue, in addition to cardiac development and healing. Periostin levels are increased in several forms of cancer, including pancreatic, ovarian, colon, lung, breast, gastric, thyroid, and esophageal head and neck carcinomas. The present review highlights the key role of periostin in tumorigenesis, particularly in increasing cell survival, invasion, angiogenesis, epithelial‑mesenchymal transition and metastasis of carcinoma cells by interacting with numerous cell‑surface receptors, including integrins, in the phosphoinositide 3-kinase-Akt pathway. In addition, periostin actively affects the canonical Wnt signaling pathway of colorectal tumorigenesis. The current review focused on the involvement of periostin in the development of colorectal, esophageal and gastric cancer.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Moniuszko T, Wincewicz A, Koda M, Domysławska I and Sulkowski S: Role of periostin in esophageal, gastric and colon cancer (Review). Oncol Lett 12: 783-787, 2016
APA
Moniuszko, T., Wincewicz, A., Koda, M., Domysławska, I., & Sulkowski, S. (2016). Role of periostin in esophageal, gastric and colon cancer (Review). Oncology Letters, 12, 783-787. https://doi.org/10.3892/ol.2016.4692
MLA
Moniuszko, T., Wincewicz, A., Koda, M., Domysławska, I., Sulkowski, S."Role of periostin in esophageal, gastric and colon cancer (Review)". Oncology Letters 12.2 (2016): 783-787.
Chicago
Moniuszko, T., Wincewicz, A., Koda, M., Domysławska, I., Sulkowski, S."Role of periostin in esophageal, gastric and colon cancer (Review)". Oncology Letters 12, no. 2 (2016): 783-787. https://doi.org/10.3892/ol.2016.4692