Open Access

Anti-tumor effect of Radix Paeoniae Rubra extract on mice bladder tumors using intravesical therapy

  • Authors:
    • Mei‑Yi Lin
    • Su‑Yin Chiang
    • Yi‑Zhen Li
    • Mei‑Fang Chen
    • Yueh‑Sheng Chen
    • Jin‑Yi Wu
    • Yi‑Wen Liu
  • View Affiliations

  • Published online on: June 9, 2016     https://doi.org/10.3892/ol.2016.4698
  • Pages: 904-910
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Radix Paeoniae Rubra (RPR) is the dried root of Paeonia lactiflora Pallas and Paeonia veitchii Lynch, and is a herbal medicine that is widely used in traditional Chinese medicine for the treatment of blood‑heat and blood‑stasis syndrome, similarly to Cortex Moutan. The present study identified the same three components in RPR and Cortex Moutan extracts. In addition, it has been reported that RPR has an anti‑cancer effect. Bladder cancer is the seventh most common type of cancer worldwide. Due to the high recurrence rate, identifying novel drugs for bladder cancer therapy is essential. In the present study, RPR extract was evaluated as a bladder cancer therapy in vitro and in vivo. The present results revealed that RPR extract reduced the cell viability of bladder cancer cells with a half maximal inhibitory concentration of 1-3 mg/ml, and had an extremely low cytotoxic effect on normal urothelial cells. Additionally, RPR decreased certain cell cycle populations, predominantly cells in the G1 phase, and caused a clear sub‑G increase. In a mouse orthotopic bladder tumor model, intravesical application of RPR extract decreased the bladder tumor size without altering the blood biochemical parameters of the mice. In summary, the present results demonstrate the anti-proliferative properties of RPR extract on bladder cancer cells, and its anti‑bladder tumor effect in vivo. Compared to Cortex Moutan extract, RPR extract may provide a more effective alternative therapeutic strategy for the intravesical therapy of superficial bladder cancer.
View Figures
View References

Related Articles

Journal Cover

August-2016
Volume 12 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Lin MY, Chiang SY, Li YZ, Chen MF, Chen YS, Wu JY and Liu YW: Anti-tumor effect of Radix Paeoniae Rubra extract on mice bladder tumors using intravesical therapy. Oncol Lett 12: 904-910, 2016
APA
Lin, M., Chiang, S., Li, Y., Chen, M., Chen, Y., Wu, J., & Liu, Y. (2016). Anti-tumor effect of Radix Paeoniae Rubra extract on mice bladder tumors using intravesical therapy. Oncology Letters, 12, 904-910. https://doi.org/10.3892/ol.2016.4698
MLA
Lin, M., Chiang, S., Li, Y., Chen, M., Chen, Y., Wu, J., Liu, Y."Anti-tumor effect of Radix Paeoniae Rubra extract on mice bladder tumors using intravesical therapy". Oncology Letters 12.2 (2016): 904-910.
Chicago
Lin, M., Chiang, S., Li, Y., Chen, M., Chen, Y., Wu, J., Liu, Y."Anti-tumor effect of Radix Paeoniae Rubra extract on mice bladder tumors using intravesical therapy". Oncology Letters 12, no. 2 (2016): 904-910. https://doi.org/10.3892/ol.2016.4698