Open Access

Hepatocellular carcinoma stem cell‑like cells are enriched following low‑dose 5‑fluorouracil chemotherapy

  • Authors:
    • Yongqiang Zhan
    • Lisha Mou
    • Kangwen Cheng
    • Chengyou Wang
    • Xuesong Deng
    • Junren Chen
    • Zhibing Fan
    • Yong Ni
  • View Affiliations

  • Published online on: August 8, 2016     https://doi.org/10.3892/ol.2016.4975
  • Pages: 2511-2516
  • Copyright: © Zhan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has been proposed that cancer stem cells (CSCs) are involved in tumor resistance to chemotherapy and tumor relapse. The goal of the present study was to determine the effect of low‑dose 5‑fluorouracil (5‑Fu) on enriched hepatocellular CSC‑like cells. Increased cell motility and epithelial‑mesenchymal transition were observed by migration assay in human hepatoblastoma PLC/RAF/5 cells following 5‑Fu treatment, as well as a significant enhancement in their sphere‑forming abilities. CSC‑like cells were identified by side population cell analysis. The percentage of CSC‑like cells in the surviving cells was greatly increased in response to 5‑Fu. These findings indicate that low‑dose 5‑Fu treatment may efficiently enrich the CSC‑like cell population in PLC/RAF/5 cells.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhan Y, Mou L, Cheng K, Wang C, Deng X, Chen J, Fan Z and Ni Y: Hepatocellular carcinoma stem cell‑like cells are enriched following low‑dose 5‑fluorouracil chemotherapy. Oncol Lett 12: 2511-2516, 2016
APA
Zhan, Y., Mou, L., Cheng, K., Wang, C., Deng, X., Chen, J. ... Ni, Y. (2016). Hepatocellular carcinoma stem cell‑like cells are enriched following low‑dose 5‑fluorouracil chemotherapy. Oncology Letters, 12, 2511-2516. https://doi.org/10.3892/ol.2016.4975
MLA
Zhan, Y., Mou, L., Cheng, K., Wang, C., Deng, X., Chen, J., Fan, Z., Ni, Y."Hepatocellular carcinoma stem cell‑like cells are enriched following low‑dose 5‑fluorouracil chemotherapy". Oncology Letters 12.4 (2016): 2511-2516.
Chicago
Zhan, Y., Mou, L., Cheng, K., Wang, C., Deng, X., Chen, J., Fan, Z., Ni, Y."Hepatocellular carcinoma stem cell‑like cells are enriched following low‑dose 5‑fluorouracil chemotherapy". Oncology Letters 12, no. 4 (2016): 2511-2516. https://doi.org/10.3892/ol.2016.4975