Anticancer effect of deoxypodophyllotoxin induces apoptosis of human prostate cancer cells

  • Authors:
    • Sheng Hu
    • Qiang Zhou
    • Wan‑Rui Wu
    • Yi‑Xing Duan
    • Zhi‑Yong Gao
    • Yuan‑Wei Li
    • Qiang Lu
  • View Affiliations

  • Published online on: August 3, 2016     https://doi.org/10.3892/ol.2016.4943
  • Pages: 2918-2923
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Abstract

Deoxypodophyllotoxin (DPPT) is extracted and separated from citrus‑related plants, including Podophyllum (P.) peltatum, P. pleianthum, P. emodi (also called P. hexandrum) and Diphylleia grayi. DPPT has significant antitumor and antiviral activity. However, due to its strong toxicity and side effects, its use is limited in practical applications. The in vitro antitumor efficacy of DPPT on human prostate cancer (PCa) cells remains to be determined. The present study investigated the anticancer effect of DPPT on human PCa cells and its potential mechanism. The data revealed that DPPT markedly reduced cell proliferation and activated the caspase‑3 expression level by an increase in apoptotic cell death in DU‑145 cells. In addition, treatment with DPPT markedly downregulated the levels of phosphorylated Akt and activated the p53/B-cell lymphoma 2 associated X protein (Bax)/phosphatase and tensin homolog (PTEN) signaling pathway in DU‑145 cells, suggesting that caspase‑mediated pathways were involved in DPPT‑induced apoptosis. The present study suggested the role of DPPT as a novel chemotherapeutic drug for human PCa, which may function through the Akt/p53/Bax/PTEN signaling pathway.
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October-2016
Volume 12 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hu S, Zhou Q, Wu WR, Duan YX, Gao ZY, Li YW and Lu Q: Anticancer effect of deoxypodophyllotoxin induces apoptosis of human prostate cancer cells. Oncol Lett 12: 2918-2923, 2016
APA
Hu, S., Zhou, Q., Wu, W., Duan, Y., Gao, Z., Li, Y., & Lu, Q. (2016). Anticancer effect of deoxypodophyllotoxin induces apoptosis of human prostate cancer cells. Oncology Letters, 12, 2918-2923. https://doi.org/10.3892/ol.2016.4943
MLA
Hu, S., Zhou, Q., Wu, W., Duan, Y., Gao, Z., Li, Y., Lu, Q."Anticancer effect of deoxypodophyllotoxin induces apoptosis of human prostate cancer cells". Oncology Letters 12.4 (2016): 2918-2923.
Chicago
Hu, S., Zhou, Q., Wu, W., Duan, Y., Gao, Z., Li, Y., Lu, Q."Anticancer effect of deoxypodophyllotoxin induces apoptosis of human prostate cancer cells". Oncology Letters 12, no. 4 (2016): 2918-2923. https://doi.org/10.3892/ol.2016.4943