MicroRNA-138 inhibits proliferation, migration and invasion through targeting hTERT in cervical cancer

  • Authors:
    • Na Zhou
    • Dan Fei
    • Shan Zong
    • Mingyue Zhang
    • Ying Yue
  • View Affiliations

  • Published online on: August 23, 2016     https://doi.org/10.3892/ol.2016.5038
  • Pages: 3633-3639
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Abstract

A growing body of evidence suggests that microRNA-138 (miR-138) functions as a tumor suppressor, and is involved in tumor initiation, development and metastasis in certain types of human cancers. However, the function and underlying molecular mechanism of miR‑138 in cervical cancer remains unclear. Therefore, the purpose of the present study was to investigate the clinical significance of miR‑138 expression in cervical cancer, and to evaluate its role and underlying mechanisms in cervical cancer. The present study indicated that miR‑138 expression was significantly downregulated in cervical cancer tissues and cell lines, and that the low miR‑138 expression was negatively associated with advanced FIGO stage and lymph node metastasis (P<0.01). Functional analyses indicated that the overexpression of miR‑138 in cervical cancer cells inhibited cell proliferation, migration and invasion, induced cell apoptosis in vitro, and suppressed tumor growth in a nude mice model. Luciferase reporter assays confirmed that human telomerase reverse transcriptase was a novel target gene of miR-138. The findings of the present study suggested that miR‑138 could be a potential candidate for cervical cancer therapeutics.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou N, Fei D, Zong S, Zhang M and Yue Y: MicroRNA-138 inhibits proliferation, migration and invasion through targeting hTERT in cervical cancer. Oncol Lett 12: 3633-3639, 2016
APA
Zhou, N., Fei, D., Zong, S., Zhang, M., & Yue, Y. (2016). MicroRNA-138 inhibits proliferation, migration and invasion through targeting hTERT in cervical cancer. Oncology Letters, 12, 3633-3639. https://doi.org/10.3892/ol.2016.5038
MLA
Zhou, N., Fei, D., Zong, S., Zhang, M., Yue, Y."MicroRNA-138 inhibits proliferation, migration and invasion through targeting hTERT in cervical cancer". Oncology Letters 12.5 (2016): 3633-3639.
Chicago
Zhou, N., Fei, D., Zong, S., Zhang, M., Yue, Y."MicroRNA-138 inhibits proliferation, migration and invasion through targeting hTERT in cervical cancer". Oncology Letters 12, no. 5 (2016): 3633-3639. https://doi.org/10.3892/ol.2016.5038