Open Access

Overexpression of microRNA‑24 increases the sensitivity to paclitaxel in drug‑resistant breast carcinoma cell lines via targeting ABCB9

  • Authors:
    • Jian‑Ping Gong
    • Liu Yang
    • Jun‑Wei Tang
    • Peng Sun
    • Qing Hu
    • Jian‑Wei Qin
    • Xiao‑Ming Xu
    • Bei‑Cheng Sun
    • Jin‑Hai Tang
  • View Affiliations

  • Published online on: September 15, 2016     https://doi.org/10.3892/ol.2016.5139
  • Pages: 3905-3911
  • Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Paclitaxel has been widely used in the treatment of breast cancer. However, the development of drug resistance often increases the failure of chemotherapy. Growing evidence has reported the significant role of microRNAs (miRs) in drug resistance. The present study identified that miR‑24 was significantly downregulated in paclitaxel‑resistant (PR) breast cancer patients and in MCF‑7/PR human breast carcinoma cells, and that overexpression of miR‑24 could increase the effect of paclitaxel on drug‑resistant breast carcinoma cells. Furthermore, miR‑24 could directly bind to the 3'‑untranslated region of ATP binding cassette B9 to downregulate its expression, thereby reducing drug transportation and improving the anti‑tumor effect of paclitaxel on breast cancer cells. In vivo experiments also demonstrated that overexpression of miR‑24 could increase the sensitivity of drug‑resistant MCF‑7 cells to paclitaxel. In conclusion, the present results suggested a novel function for miR‑24 in reducing paclitaxel resistance in breast cancer, which may be of important clinical significance.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Gong JP, Yang L, Tang JW, Sun P, Hu Q, Qin JW, Xu XM, Sun BC and Tang JH: Overexpression of microRNA‑24 increases the sensitivity to paclitaxel in drug‑resistant breast carcinoma cell lines via targeting ABCB9. Oncol Lett 12: 3905-3911, 2016
APA
Gong, J., Yang, L., Tang, J., Sun, P., Hu, Q., Qin, J. ... Tang, J. (2016). Overexpression of microRNA‑24 increases the sensitivity to paclitaxel in drug‑resistant breast carcinoma cell lines via targeting ABCB9. Oncology Letters, 12, 3905-3911. https://doi.org/10.3892/ol.2016.5139
MLA
Gong, J., Yang, L., Tang, J., Sun, P., Hu, Q., Qin, J., Xu, X., Sun, B., Tang, J."Overexpression of microRNA‑24 increases the sensitivity to paclitaxel in drug‑resistant breast carcinoma cell lines via targeting ABCB9". Oncology Letters 12.5 (2016): 3905-3911.
Chicago
Gong, J., Yang, L., Tang, J., Sun, P., Hu, Q., Qin, J., Xu, X., Sun, B., Tang, J."Overexpression of microRNA‑24 increases the sensitivity to paclitaxel in drug‑resistant breast carcinoma cell lines via targeting ABCB9". Oncology Letters 12, no. 5 (2016): 3905-3911. https://doi.org/10.3892/ol.2016.5139