Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF‑κB

  • Authors:
    • Helia Judith Pimentel-Gutiérrez
    • Lucina Bobadilla-Morales
    • César Cenobio Barba-Barba
    • Citlalli Ortega-De-La-Torre
    • Fernando Antonio Sánchez-Zubieta
    • Jorge Román Corona-Rivera
    • Betsy Annel González-Quezada
    • Juan S. Armendáriz-Borunda
    • Rocío Silva-Cruz
    • Alfredo Corona-Rivera
  • View Affiliations

  • Published online on: September 30, 2016     https://doi.org/10.3892/ol.2016.5217
  • Pages: 4117-4124
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Abstract

Acute lymphoblastic leukemia (ALL) accounts for 30% of all pediatric cancers. Currently available treatments exhibit toxicity and certain patients may develop resistance. Thus, less toxic and chemoresistance‑reversal agents are required. In the present study, the potential effect of curcumin, a component of Curcuma longa, as a pharmacological co‑adjuvant of several chemotherapeutic agents against ALL, including prednisone, 6‑mercaptopurine, dexamethasone, cyclophosphamide, l‑asparaginase, vincristine, daunorubicin, doxorubicin, methotrexate and cytarabine, was investigated in the REH ALL cell line cultures treated in combination with chemotherapeutic agents and curcumin. The results of cell viability, gene expression and activation of NF-κB and caspase 3 indicated that curcumin potentiates the anticancer effects of the aforementioned chemotherapeutic agents in the REH ALL cell line. Following treatment with the above chemotherapeutic agents, curcumin enhanced caspase‑3 activation and downregulated nuclear factor‑kappa B (NF‑κB) activation. Curcumin also downregulated the oxidative stress induced by certain chemotherapies. Notably, curcumin did not affect the gene expression of cell survival proteins such as B‑cell lymphoma (Bcl)‑2, Bcl‑extra large, survivin, c‑Myc and cyclin D1, which are regulated by the NF‑κB transcription factor. In conclusion, curcumin has the potential to improve the effect of chemotherapeutic agents against ALL.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Pimentel-Gutiérrez HJ, Bobadilla-Morales L, Barba-Barba CC, Ortega-De-La-Torre C, Sánchez-Zubieta FA, Corona-Rivera JR, González-Quezada BA, Armendáriz-Borunda JS, Silva-Cruz R, Corona-Rivera A, Corona-Rivera A, et al: Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF‑κB. Oncol Lett 12: 4117-4124, 2016
APA
Pimentel-Gutiérrez, H.J., Bobadilla-Morales, L., Barba-Barba, C.C., Ortega-De-La-Torre, C., Sánchez-Zubieta, F.A., Corona-Rivera, J.R. ... Corona-Rivera, A. (2016). Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF‑κB. Oncology Letters, 12, 4117-4124. https://doi.org/10.3892/ol.2016.5217
MLA
Pimentel-Gutiérrez, H. J., Bobadilla-Morales, L., Barba-Barba, C. C., Ortega-De-La-Torre, C., Sánchez-Zubieta, F. A., Corona-Rivera, J. R., González-Quezada, B. A., Armendáriz-Borunda, J. S., Silva-Cruz, R., Corona-Rivera, A."Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF‑κB". Oncology Letters 12.5 (2016): 4117-4124.
Chicago
Pimentel-Gutiérrez, H. J., Bobadilla-Morales, L., Barba-Barba, C. C., Ortega-De-La-Torre, C., Sánchez-Zubieta, F. A., Corona-Rivera, J. R., González-Quezada, B. A., Armendáriz-Borunda, J. S., Silva-Cruz, R., Corona-Rivera, A."Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF‑κB". Oncology Letters 12, no. 5 (2016): 4117-4124. https://doi.org/10.3892/ol.2016.5217