Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation

  • Authors:
    • Jun Han
    • Qiulei Xi
    • Qingyang Meng
    • Jingzheng Liu
    • Yongxian Zhang
    • Yusong Han
    • Qiulin Zhuang
    • Yi Jiang
    • Qiurong Ding
    • Guohao Wu
  • View Affiliations

  • Published online on: October 5, 2016     https://doi.org/10.3892/ol.2016.5227
  • Pages: 4665-4670
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Abstract

Interleukin-6 (IL-6) is a well-known etiological factor of colitis‑associated colorectal cancer (CAC) and has a significant role in CAC progression. In addition, hypoxia‑inducible factor 1α (HIF‑1α) serves a primary role in the progression of CAC. However, the association between IL‑6 and HIF‑1α during the progression of CAC remains unclear. To investigate this association, the present study induced CAC in a mouse model using azoxymethane and dextran sulfate sodium. In addition, an anti‑IL‑6 receptor antibody was used to inhibit IL‑6. In this model, anti‑IL‑6 receptor antibody treatment significantly inhibited the development of CAC and the expression of HIF‑1α, in colorectal adenomas and adenocarcinomas. In patients with CAC, the HIF‑1α gene was demonstrated to be overexpressed in tumor tissue compared with adjacent non‑malignant tissue. Furthermore, HIF‑1α mRNA expression was positively correlated with serum IL‑6 concentration. The results of the present study suggest that IL‑6 promotes CAC progression, in the early stage of the disease, through HIF-1α regulation.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Han J, Xi Q, Meng Q, Liu J, Zhang Y, Han Y, Zhuang Q, Jiang Y, Ding Q, Wu G, Wu G, et al: Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation. Oncol Lett 12: 4665-4670, 2016
APA
Han, J., Xi, Q., Meng, Q., Liu, J., Zhang, Y., Han, Y. ... Wu, G. (2016). Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation. Oncology Letters, 12, 4665-4670. https://doi.org/10.3892/ol.2016.5227
MLA
Han, J., Xi, Q., Meng, Q., Liu, J., Zhang, Y., Han, Y., Zhuang, Q., Jiang, Y., Ding, Q., Wu, G."Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation". Oncology Letters 12.6 (2016): 4665-4670.
Chicago
Han, J., Xi, Q., Meng, Q., Liu, J., Zhang, Y., Han, Y., Zhuang, Q., Jiang, Y., Ding, Q., Wu, G."Interleukin-6 promotes tumor progression in colitis‑associated colorectal cancer through HIF-1α regulation". Oncology Letters 12, no. 6 (2016): 4665-4670. https://doi.org/10.3892/ol.2016.5227