Open Access

Correlations between the MEG-A3 gene and incidence of breast cancer

  • Authors:
    • Xinming Hou
    • Feng Guo
    • Qinghui Sun
  • View Affiliations

  • Published online on: October 27, 2016     https://doi.org/10.3892/ol.2016.5325
  • Pages: 4925-4928
  • Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to examine the interrelations between MEG-A3 gene and incidence of breast cancer. The expression of MEG-A3 gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same patient was measured at different time-points (1, 3, 6, 8, 12 and 24 months), and the protein expression levels were determined using western blotting. The results showed that, the mRNA level in MEG-A3 gene of samples of patients with breast cancer was significantly higher than that of normal women (p<0.05). The MEG-A3 gene expression increased apparently with the prolongation and aggravation of the disease. In conclusion, there is a close correlation between MEG-A3 gene and the incidence of breast cancer; thus, MEG-A3 gene contributes to the occurrence and deterioration of breast cancer to some extent. It provides a theoretical basis for later disease treatment.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hou X, Guo F and Sun Q: Correlations between the MEG-A3 gene and incidence of breast cancer. Oncol Lett 12: 4925-4928, 2016
APA
Hou, X., Guo, F., & Sun, Q. (2016). Correlations between the MEG-A3 gene and incidence of breast cancer. Oncology Letters, 12, 4925-4928. https://doi.org/10.3892/ol.2016.5325
MLA
Hou, X., Guo, F., Sun, Q."Correlations between the MEG-A3 gene and incidence of breast cancer". Oncology Letters 12.6 (2016): 4925-4928.
Chicago
Hou, X., Guo, F., Sun, Q."Correlations between the MEG-A3 gene and incidence of breast cancer". Oncology Letters 12, no. 6 (2016): 4925-4928. https://doi.org/10.3892/ol.2016.5325