Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells

  • Authors:
    • Yong'an Chen
    • Yusong Bian
    • Shanpeng Zhao
    • Fanqiang Kong
    • Xin'gang Li
  • View Affiliations

  • Published online on: October 27, 2016     https://doi.org/10.3892/ol.2016.5323
  • Pages: 5170-5176
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Abstract

Programmed cell death protein 4 (PDCD4) has recently been demonstrated to be implicated in translation and transcription, and the regulation of cell growth. However, the mechanisms underlying PDCD4 function in glioma cells remain to be elucidated. The current study investigated the function and regulation of PDCD4 and the results demonstrated that the expression of PDCD4 was significantly reduced in glioma cells compared with normal cells. When PDCD4 was overexpressed in glioma cells, the proliferation rate and invasive capability of the cells greatly decreased, suggesting that PDCD4 functions as a tumor suppressor in this cell type. In addition, the histone modification status of the PDCD4 gene was analyzed, and chromatin immunoprecipitation assay identified a high density of histone 3 lysine 27 trimethylation on the promoter of PDCD4, which was associated with the long non‑coding RNA, homeobox transcript antisense RNA (HOTAIR). The expression of HOTAIR was significantly increased in glioma cells compared with normal cells, and it exerted its function in a polycomb repressive complex 2‑dependent manner. These results may provide novel approaches to therapeutically target PDCD4 and HOTAIR in patients with gliomas.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen Y, Bian Y, Zhao S, Kong F and Li X: Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells. Oncol Lett 12: 5170-5176, 2016
APA
Chen, Y., Bian, Y., Zhao, S., Kong, F., & Li, X. (2016). Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells. Oncology Letters, 12, 5170-5176. https://doi.org/10.3892/ol.2016.5323
MLA
Chen, Y., Bian, Y., Zhao, S., Kong, F., Li, X."Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells". Oncology Letters 12.6 (2016): 5170-5176.
Chicago
Chen, Y., Bian, Y., Zhao, S., Kong, F., Li, X."Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells". Oncology Letters 12, no. 6 (2016): 5170-5176. https://doi.org/10.3892/ol.2016.5323