Open Access

Inhibitory effect of Ginkgol C17:1 on the biological behavior of tumor cells

  • Authors:
    • Yueying Li
    • Jun Liu
    • Yali Liu
    • Xiaoming Yang
    • Bingzhong Huang
    • Min Chen
  • View Affiliations

  • Published online on: February 1, 2017     https://doi.org/10.3892/ol.2017.5664
  • Pages: 1873-1879
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ginkgol C17:1 is a bioactive compound derived from Ginkgo biloba. In the present study, the effect and possible mechanisms of action of Ginkgol C17:1 on the biological behaviors of tumor cells were investigated. Whilst cell proliferation was assessed using the MTT assay, the behaviors of cell migration and invasion were explored using Transwell and modified Transwell assays. The results revealed that Ginkgol C17:1 significantly inhibited the proliferation, migration and invasion of human tumor cells in a dose‑dependent manner. Furthermore, due to their associations with the biological behaviors of tumor cells, the protein expression of matrix metalloproteinase (MMP)‑7, Ras homolog gene family, member A (RhoA) and phosphorylated‑protein kinase B (Akt) was analyzed by western blotting. The results showed that the expression of the aforementioned proteins was decreased markedly following Ginkgol C17:1 treatment. The results of the present study suggested that Ginkgol C17:1 suppresses the biological behaviors of tumor cells by inhibiting the activation of the mitogen‑activated protein kinase/MMP, Rho/Rho‑associated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways.
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March-2017
Volume 13 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li Y, Liu J, Liu Y, Yang X, Huang B and Chen M: Inhibitory effect of Ginkgol C17:1 on the biological behavior of tumor cells. Oncol Lett 13: 1873-1879, 2017
APA
Li, Y., Liu, J., Liu, Y., Yang, X., Huang, B., & Chen, M. (2017). Inhibitory effect of Ginkgol C17:1 on the biological behavior of tumor cells. Oncology Letters, 13, 1873-1879. https://doi.org/10.3892/ol.2017.5664
MLA
Li, Y., Liu, J., Liu, Y., Yang, X., Huang, B., Chen, M."Inhibitory effect of Ginkgol C17:1 on the biological behavior of tumor cells". Oncology Letters 13.3 (2017): 1873-1879.
Chicago
Li, Y., Liu, J., Liu, Y., Yang, X., Huang, B., Chen, M."Inhibitory effect of Ginkgol C17:1 on the biological behavior of tumor cells". Oncology Letters 13, no. 3 (2017): 1873-1879. https://doi.org/10.3892/ol.2017.5664