Open Access

Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC

  • Authors:
    • Yinzhou Xiang
    • Fen Li
    • Lei Wang
    • Anyuan Zheng
    • Jingjing Zuo
    • Man Li
    • Yongping Wang
    • Yong Xu
    • Chen Chen
    • Shiming Chen
    • Bokui Xiao
    • Zezhang Tao
  • View Affiliations

  • Published online on: February 7, 2017     https://doi.org/10.3892/ol.2017.5687
  • Pages: 2237-2243
  • Copyright: © Xiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Calpains are a family of intracellular cysteine proteases involved in various biological processes. Previously, the family was identified to have abnormal expression in several types of malignant tumor. Calpain 6 was less well known; however, it was recently identified to be involved in the carcinogenesis of certain types of malignant tumor. However, the expression of calpain 6 in head and neck squamous cell carcinoma (HNSCC) remains unclear. A total of six datasets from the Gene Expression Omnibus (GEO) was analyzed and an association between calpain 6 expression levels and HNSCC was identified, with the expression of calpain 6 observed to be significantly decreased in HNSCC (P<0.01). However, the expression of calpain 6 may vary between distinct tumor stages of HNSCC. Furthermore, calpain 6 expression was positively associated with the survival rate in patients with HNSCC (P<0.05), with increased expression of calpain 6 associated with an improved survival outcome. Calpain 6 expression was analyzed using an HNSCC tissue microarray and these results were consistent with the statistical analysis of the bioinformatics data from the GEO, indicating that calpain 6 may be a tumor suppressor protein in HNSCC.

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April-2017
Volume 13 Issue 4

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Spandidos Publications style
Xiang Y, Li F, Wang L, Zheng A, Zuo J, Li M, Wang Y, Xu Y, Chen C, Chen S, Chen S, et al: Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC. Oncol Lett 13: 2237-2243, 2017
APA
Xiang, Y., Li, F., Wang, L., Zheng, A., Zuo, J., Li, M. ... Tao, Z. (2017). Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC. Oncology Letters, 13, 2237-2243. https://doi.org/10.3892/ol.2017.5687
MLA
Xiang, Y., Li, F., Wang, L., Zheng, A., Zuo, J., Li, M., Wang, Y., Xu, Y., Chen, C., Chen, S., Xiao, B., Tao, Z."Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC". Oncology Letters 13.4 (2017): 2237-2243.
Chicago
Xiang, Y., Li, F., Wang, L., Zheng, A., Zuo, J., Li, M., Wang, Y., Xu, Y., Chen, C., Chen, S., Xiao, B., Tao, Z."Decreased calpain 6 expression is associated with tumorigenesis and poor prognosis in HNSCC". Oncology Letters 13, no. 4 (2017): 2237-2243. https://doi.org/10.3892/ol.2017.5687