Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer

  • Authors:
    • Yuchong Yang
    • Bin Ma
    • Ying Yan
    • Yongxi Song
    • Peng Gao
    • Jingxu Sun
    • Jiajun Wang
    • Zhenning Wang
  • View Affiliations

  • Published online on: May 17, 2017     https://doi.org/10.3892/ol.2017.6186
  • Pages: 1068-1072
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Abstract

A long non-coding RNA named HOXA transcript at the distal tip (HOTTIP) has been reported to be significantly increased in several cancers, including hepatocellular cancer, pancreatic cancer and lung cancer. However, the clinical value of HOTTIP expression in gastric cancer remains unknown. The present study aimed to investigate HOTTIP expression levels in gastric cancer and to elucidate its clinical significance. Reverse transcription polymerase chain reaction was used to assess the expression level of HOTTIP in gastric cancer cell lines and tissues. In a cohort of 94 patients with gastric cancer, HOTTIP expression was significantly lower in cancer tissues compared with the normal adjacent tissues. In addition, receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of HOTTIP in gastric cancer, and the area under the ROC curve was 0.767. In conclusion, the results of the present study indicated that HOTTIP may be a predictive biomarker for gastric cancer.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yang Y, Ma B, Yan Y, Song Y, Gao P, Sun J, Wang J and Wang Z: Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer. Oncol Lett 14: 1068-1072, 2017
APA
Yang, Y., Ma, B., Yan, Y., Song, Y., Gao, P., Sun, J. ... Wang, Z. (2017). Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer. Oncology Letters, 14, 1068-1072. https://doi.org/10.3892/ol.2017.6186
MLA
Yang, Y., Ma, B., Yan, Y., Song, Y., Gao, P., Sun, J., Wang, J., Wang, Z."Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer". Oncology Letters 14.1 (2017): 1068-1072.
Chicago
Yang, Y., Ma, B., Yan, Y., Song, Y., Gao, P., Sun, J., Wang, J., Wang, Z."Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer". Oncology Letters 14, no. 1 (2017): 1068-1072. https://doi.org/10.3892/ol.2017.6186