Open Access

Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review)

  • Authors:
    • Guodong Deng
    • Ning Liang
    • Jian Xie
    • Hui Luo
    • Lili Qiao
    • Jingxin Zhang
    • Dawei Wang
    • Jiandong Zhang
  • View Affiliations

  • Published online on: May 26, 2017     https://doi.org/10.3892/ol.2017.6268
  • Pages: 501-511
  • Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Radiation-induced lung injury (RILI) remains a major obstacle for thoracic radiotherapy for the treatment of lung cancer, esophageal cancer and lymphoma. It is the principal dose‑limiting complication, and can markedly impair the therapeutic ratio as well as a patient's quality of life. The current review presents the relevant concepts associated with RILI, including the pathogenic mechanisms and the potential treatment strategies, so as to achieve a general understanding of this issue. RILI comprises an acute radiation pneumonitis phase and subsequent late lung fibrosis. The established assessment criteria are clinical manifestations, imaging changes and the necessity for medical assistance. Risk factors are also considered in order to optimize treatment planning. Due to the underlying molecular mechanisms of RILI, the present review also discusses several targeted pharmacological approaches for its treatment, as well as corticosteroid therapy.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Deng G, Liang N, Xie J, Luo H, Qiao L, Zhang J, Wang D and Zhang J: Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review). Oncol Lett 14: 501-511, 2017
APA
Deng, G., Liang, N., Xie, J., Luo, H., Qiao, L., Zhang, J. ... Zhang, J. (2017). Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review). Oncology Letters, 14, 501-511. https://doi.org/10.3892/ol.2017.6268
MLA
Deng, G., Liang, N., Xie, J., Luo, H., Qiao, L., Zhang, J., Wang, D., Zhang, J."Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review)". Oncology Letters 14.1 (2017): 501-511.
Chicago
Deng, G., Liang, N., Xie, J., Luo, H., Qiao, L., Zhang, J., Wang, D., Zhang, J."Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review)". Oncology Letters 14, no. 1 (2017): 501-511. https://doi.org/10.3892/ol.2017.6268