Open Access

Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines

  • Authors:
    • Eriko Tanabe
    • Misaho Kitayoshi
    • Kiyomu Fujii
    • Hitoshi Ohmori
    • Yi Luo
    • Yui Kadochi
    • Shiori Mori
    • Rina Fujiwara
    • Yukiko Nishiguchi
    • Takamitsu Sasaki
    • Hiroki Kuniyasu
  • View Affiliations

  • Published online on: May 17, 2017     https://doi.org/10.3892/ol.2017.6190
  • Pages: 681-686
  • Copyright: © Tanabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study investigated the effects of two major dietary fatty acid components, linoleic acid (LA) and elaidic acid (EA), on the antitumor effects of 5-fluorouracil (5‑FU) in the LL2, CT26 and CMT93 mouse cancer cell lines. Concurrent treatment with LA and 5‑FU elicited a decreased cell viability compared with treatment with 5‑FU alone. In addition, increased inhibition of growth was observed following concurrent treatment with EA and 5‑FU. Sequential treatment of LA followed by 5‑FU abrogated the anticancer effects of 5‑FU, and treatment with EA followed by 5‑FU increased cancer cell growth in addition to abrogating the anticancer effects of 5‑FU. The expression of the stem cell markers CD133 and nucleostemin (NS) increased in all three cell lines treated concurrently with 5‑FU and either LA or EA when compared with cells treated with 5‑FU alone. Aldehyde dehydrogenase activity in the cancer stem cells (CSCs), in response to concurrent treatment with 5‑FU and either LA or EA, was increased compared with 5‑FU treatment alone. 5‑FU inhibited the growth of CT26 tumors, but co‑treatment with either LA or EA abrogated this effect. NS‑positive CSCs were more abundant in CT26 tumors treated with 5‑FU and either LA or EA compared with those treated with 5‑FU alone. The results of the present study suggested that, rather than altering the sensitivity of cancer cells to 5‑FU, LA and EA may promote the survival of CSCs. The results indicated that dietary composition during chemotherapy is an important issue.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Kadochi Y, Mori S, Fujiwara R, Nishiguchi Y, Sasaki T, Sasaki T, et al: Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines. Oncol Lett 14: 681-686, 2017
APA
Tanabe, E., Kitayoshi, M., Fujii, K., Ohmori, H., Luo, Y., Kadochi, Y. ... Kuniyasu, H. (2017). Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines. Oncology Letters, 14, 681-686. https://doi.org/10.3892/ol.2017.6190
MLA
Tanabe, E., Kitayoshi, M., Fujii, K., Ohmori, H., Luo, Y., Kadochi, Y., Mori, S., Fujiwara, R., Nishiguchi, Y., Sasaki, T., Kuniyasu, H."Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines". Oncology Letters 14.1 (2017): 681-686.
Chicago
Tanabe, E., Kitayoshi, M., Fujii, K., Ohmori, H., Luo, Y., Kadochi, Y., Mori, S., Fujiwara, R., Nishiguchi, Y., Sasaki, T., Kuniyasu, H."Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines". Oncology Letters 14, no. 1 (2017): 681-686. https://doi.org/10.3892/ol.2017.6190