Open Access

Intranuclear accumulation of galectin-3 is an independent prognostic factor for patients with distal cholangiocarcinoma

  • Authors:
    • Tatsuo Shimura
    • Yasuhide Kofunato
    • Ryo Okada
    • Rei Yashima
    • Yoshihisa Koyama
    • Kenichiro Araki
    • Hiroyuki Kuwano
    • Seiichi Takenoshita
  • View Affiliations

  • Published online on: May 25, 2017     https://doi.org/10.3892/ol.2017.6252
  • Pages: 819-829
  • Copyright: © Shimura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Galectin-3 has been reported to be associated with the prognosis of patients with various malignancies; however, it has not yet been investigated in patients with extrahepatic cholangiocarcinoma (EHCC). Expression of galectin-3 was retrospectively examined in 58 patients with EHCC: 21 with perihilar cholangiocarcinoma and 37 with distal cholangiocarcinoma (DCC). The Cox proportional hazard model was used to identify independent prognostic factors. Intranuclear accumulation of galectin‑3 (gal‑3‑INA) was associated with poorer overall survival (OS) in all patients (P=0.003), as well as in patients with DCC (P=0.004). Patients with gal‑3‑INA also exhibited a poorer disease‑free survival (DFS) than those without gal‑3‑INA in all patients with EHCC (P<0.001), and in patients with DCC (P<0.001). Gal‑3‑INA was an independent prognostic factor of OS and DFS in all patients [OS: Hazard ratio (HR), 4.470; 95% confidence interval (CI), 1.759‑11.357; P=0.002; and DFS: HR, 5.116; 95% CI, 2.025‑12.925; P=0.001]. Gal‑3‑INA was also an independent prognostic factor in patients with DCC (OS: HR, 2.979; 95% CI, 1.035‑8.570; P=0.043; and DFS: HR, 6.773; 95% CI, 1.558‑29.439; P=0.011). In the analysis of patients with DCC, the number of patients with high galectin‑3 expression (P=0.038), recurrence (P<0.001), distant metastases (P<0.001), R0 status (P=0.029) or microscopic vascular invasion (P=0.019) was significantly higher in the gal‑3‑INA‑positive group than in the gal‑3‑INA‑negative group. In conclusion, gal‑3‑INA was identified as a strong prognostic factor for OS and DFS in patients with DCC.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shimura T, Kofunato Y, Okada R, Yashima R, Koyama Y, Araki K, Kuwano H and Takenoshita S: Intranuclear accumulation of galectin-3 is an independent prognostic factor for patients with distal cholangiocarcinoma. Oncol Lett 14: 819-829, 2017
APA
Shimura, T., Kofunato, Y., Okada, R., Yashima, R., Koyama, Y., Araki, K. ... Takenoshita, S. (2017). Intranuclear accumulation of galectin-3 is an independent prognostic factor for patients with distal cholangiocarcinoma. Oncology Letters, 14, 819-829. https://doi.org/10.3892/ol.2017.6252
MLA
Shimura, T., Kofunato, Y., Okada, R., Yashima, R., Koyama, Y., Araki, K., Kuwano, H., Takenoshita, S."Intranuclear accumulation of galectin-3 is an independent prognostic factor for patients with distal cholangiocarcinoma". Oncology Letters 14.1 (2017): 819-829.
Chicago
Shimura, T., Kofunato, Y., Okada, R., Yashima, R., Koyama, Y., Araki, K., Kuwano, H., Takenoshita, S."Intranuclear accumulation of galectin-3 is an independent prognostic factor for patients with distal cholangiocarcinoma". Oncology Letters 14, no. 1 (2017): 819-829. https://doi.org/10.3892/ol.2017.6252