Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents

  • Authors:
    • Lihe Jiang
    • Lichuan Wu
    • Fangfang Yang
    • Nadin Almosnid
    • Xu Liu
    • Jun Jiang
    • Elliot Altman
    • Lisheng Wang
    • Ying Gao
  • View Affiliations

  • Published online on: June 23, 2017     https://doi.org/10.3892/ol.2017.6475
  • Pages: 3057-3064
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Abstract

A total of five matrine derivatives were synthesized and evaluated for their anti‑proliferation activity using a panel of four human cancer cell lines, including A549 lung, BT20 breast, MCF‑7 breast and U2OS osteosarcoma cells. The YF3‑5, YF3‑7 and YF3‑9, three novel compounds, demonstrated increased anti‑proliferation activity compared with matrine, of which YF3‑5 revealed the strongest anti‑proliferation activity with a half‑maximal inhibitory concentration value of 15.49‑16.67 µM against the four human cancer cell lines. The anti‑proliferation mechanism underlying YF3‑5 was investigated in the A549 human lung cancer cell line and the results demonstrated that YF3‑5 exerted its anti‑proliferation activity through the induction of apoptosis and oxidative stress, in addition to arresting the cell cycle at the G1 phase in a dose‑dependent manner.
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September-2017
Volume 14 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jiang L, Wu L, Yang F, Almosnid N, Liu X, Jiang J, Altman E, Wang L and Gao Y: Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents. Oncol Lett 14: 3057-3064, 2017
APA
Jiang, L., Wu, L., Yang, F., Almosnid, N., Liu, X., Jiang, J. ... Gao, Y. (2017). Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents. Oncology Letters, 14, 3057-3064. https://doi.org/10.3892/ol.2017.6475
MLA
Jiang, L., Wu, L., Yang, F., Almosnid, N., Liu, X., Jiang, J., Altman, E., Wang, L., Gao, Y."Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents". Oncology Letters 14.3 (2017): 3057-3064.
Chicago
Jiang, L., Wu, L., Yang, F., Almosnid, N., Liu, X., Jiang, J., Altman, E., Wang, L., Gao, Y."Synthesis, biological evaluation and mechanism studies of matrine derivatives as anticancer agents". Oncology Letters 14, no. 3 (2017): 3057-3064. https://doi.org/10.3892/ol.2017.6475