LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway

  • Authors:
    • Junhua Luo
    • Jing Chen
    • Hang Li
    • Yu Yang
    • Haichao Yun
    • Shangqi Yang
    • Xiangming Mao
  • View Affiliations

  • Published online on: September 4, 2017     https://doi.org/10.3892/ol.2017.6886
  • Pages: 5556-5562
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The long non‑coding RNA (lncRNA) urothelial carcinoma associated 1 (UCA1) is an oncogenic lncRNA in bladder cancer, and its upregulation is associated with enhanced cell invasion. However, the underlying mechanism remains to be elucidated. The present study demonstrated that UCA1 was positively associated with cell invasion ability and promoted epithelial‑mesenchymal transition (EMT) of bladder cancer cells by inducing high mobility group box 1 (HMGB1). Furthermore, bioinformatics and luciferase reporter assays demonstrated binding sites of the tumor suppressive miR‑143 within UCA1 and the 3'untranslated region of HMGB1. UCA1 negatively regulated miR‑143 expression in a dose‑dependent manner in bladder cancer cells. In addition, UCA1 and HMGB1 were upregulated and miR‑143 was downregulated in bladder cancer specimens. Overall, the data suggested that UCA1 may promote the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway, which exhibits an important regulatory role in the pathology of bladder cancer.
View Figures
View References

Related Articles

Journal Cover

November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Luo J, Chen J, Li H, Yang Y, Yun H, Yang S and Mao X: LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway. Oncol Lett 14: 5556-5562, 2017
APA
Luo, J., Chen, J., Li, H., Yang, Y., Yun, H., Yang, S., & Mao, X. (2017). LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway. Oncology Letters, 14, 5556-5562. https://doi.org/10.3892/ol.2017.6886
MLA
Luo, J., Chen, J., Li, H., Yang, Y., Yun, H., Yang, S., Mao, X."LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway". Oncology Letters 14.5 (2017): 5556-5562.
Chicago
Luo, J., Chen, J., Li, H., Yang, Y., Yun, H., Yang, S., Mao, X."LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR‑143/HMGB1 pathway". Oncology Letters 14, no. 5 (2017): 5556-5562. https://doi.org/10.3892/ol.2017.6886