Open Access

Inhibition of cyclooxygenase‑2 sensitizes lung cancer cells to radiation‑induced apoptosis

Corrigendum in: /10.3892/ol.2019.10268

  • Authors:
    • Zhi‑Qiang Han
    • Hongwei Liao
    • Feng Shi
    • Xiao‑Ping Chen
    • Hua‑Cheng Hu
    • Ming‑Qing Tian
    • Li‑Hua Wang
    • Songmin Ying
  • View Affiliations

  • Published online on: September 14, 2017     https://doi.org/10.3892/ol.2017.6940
  • Pages: 5959-5965
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Radiotherapy resistance is an enduring major setback in lung cancer therapy, and is responsible for a large proportion of treatment failures. In previous years, cyclooxygenase‑2 (COX‑2) has frequently been reported to promote tumor occurrence and development, suggesting a potential role in radiotherapy resistance. To investigate whether COX‑2 inhibitors can be applied in radiosensitization, an MTT assay was performed to examine cell viability after X‑ray radiation in the presence or absence of the specific COX‑2 inhibitor Celecoxib. Cell apoptosis and cell cycle changes were also detected through laser confocal scanning microcopy and flow cytometry. X‑ray treatment only caused mild cell death in lung cancer A549 cells. However, combination treatment using celecoxib and X‑ray radiation exhibited improved inhibitory effects and significantly suppressed cell proliferation. Therefore, COX‑2 inhibitors combined with radiotherapy can counteract radiation‑induced high COX‑2 expression, demonstrating that celecoxib can function as a radiosensitizer of lung cancer cells. It is therefore reasonable to predict COX‑2 inhibitors to be potential clinical radiotherapy synergists.
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November-2017
Volume 14 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Han ZQ, Liao H, Shi F, Chen XP, Hu HC, Tian MQ, Wang LH and Ying S: Inhibition of cyclooxygenase‑2 sensitizes lung cancer cells to radiation‑induced apoptosis Corrigendum in /10.3892/ol.2019.10268. Oncol Lett 14: 5959-5965, 2017
APA
Han, Z., Liao, H., Shi, F., Chen, X., Hu, H., Tian, M. ... Ying, S. (2017). Inhibition of cyclooxygenase‑2 sensitizes lung cancer cells to radiation‑induced apoptosis Corrigendum in /10.3892/ol.2019.10268. Oncology Letters, 14, 5959-5965. https://doi.org/10.3892/ol.2017.6940
MLA
Han, Z., Liao, H., Shi, F., Chen, X., Hu, H., Tian, M., Wang, L., Ying, S."Inhibition of cyclooxygenase‑2 sensitizes lung cancer cells to radiation‑induced apoptosis Corrigendum in /10.3892/ol.2019.10268". Oncology Letters 14.5 (2017): 5959-5965.
Chicago
Han, Z., Liao, H., Shi, F., Chen, X., Hu, H., Tian, M., Wang, L., Ying, S."Inhibition of cyclooxygenase‑2 sensitizes lung cancer cells to radiation‑induced apoptosis Corrigendum in /10.3892/ol.2019.10268". Oncology Letters 14, no. 5 (2017): 5959-5965. https://doi.org/10.3892/ol.2017.6940