High levels of DEPDC1B predict shorter biochemical recurrence‑free survival of patients with prostate cancer

  • Authors:
    • Shoumin Bai
    • Ting Chen
    • Tao Du
    • Xianju Chen
    • Yiming Lai
    • Xiaoming Ma
    • Wanhua Wu
    • Chunhao Lin
    • Leyuan Liu
    • Hai Huang
  • View Affiliations

  • Published online on: September 22, 2017     https://doi.org/10.3892/ol.2017.7027
  • Pages:6801-6808
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Abstract

DEP domain‑containing protein 1B (DEPDC1B) has been reported to serve important functions in breast cancer and non‑small cell lung cancer. However, its involvement in the development of prostate cancer (PCa) remains unclear. Therefore, the present study aimed to investigate the expression and clinical significance of DEPDC1B in tumor tissues from patients diagnosed with PCa. A total of 80 prostate tissue samples were collected following prostatectomy to generate a tissue microarray for immunohistochemical analysis of DEPDC1B protein expression. High throughput sequencing of mRNAs from 179 prostate tissue samples, either from patients with PCa or from healthy controls, was included in the Taylor dataset. The expression levels of DEPDC1B in tumor tissues from patients with PCa were revealed to be significantly increased compared with those in normal prostate tissues (P=0.039). Increased expression of DEPDC1B was significantly associated with advanced clinical stage (P=0.006), advanced T stage (P=0.012) and lymph node metastasis (P=0.004). Kaplan‑Meier analysis demonstrated that patients with high levels of DEPDC1B mRNA had significantly shorter biochemical recurrence (BCR)‑free survival times. Multivariate analysis using Cox proportional hazards model revealed that levels of DEPDC1B mRNA were significant independent predictors of BCR‑free survival time of patients with PCa. Therefore, the expression of DEPDC1B may be used as an independent predictor of biochemical recurrence‑free survival time of patients with PCa.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Bai, S., Chen, T., Du, T., Chen, X., Lai, Y., Ma, X. ... Huang, H. (2017). High levels of DEPDC1B predict shorter biochemical recurrence‑free survival of patients with prostate cancer. Oncology Letters, 14, 6801-6808. https://doi.org/10.3892/ol.2017.7027
MLA
Bai, S., Chen, T., Du, T., Chen, X., Lai, Y., Ma, X., Wu, W., Lin, C., Liu, L., Huang, H."High levels of DEPDC1B predict shorter biochemical recurrence‑free survival of patients with prostate cancer". Oncology Letters 14.6 (2017): 6801-6808.
Chicago
Bai, S., Chen, T., Du, T., Chen, X., Lai, Y., Ma, X., Wu, W., Lin, C., Liu, L., Huang, H."High levels of DEPDC1B predict shorter biochemical recurrence‑free survival of patients with prostate cancer". Oncology Letters 14, no. 6 (2017): 6801-6808. https://doi.org/10.3892/ol.2017.7027