Expression and function of tetraspanin 1 in esophageal carcinoma

  • Authors:
    • Tingting Gu
    • Weiwei Chen
    • Li Chen
    • Guilan Wang
    • Tiejun Li
    • Yuanyuan Zhu
    • Xiaojiao Gao
  • View Affiliations

  • Published online on: September 22, 2017     https://doi.org/10.3892/ol.2017.7028
  • Pages:6815-6822
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Abstract

The present study explored the expression of tetraspanin 1 (TSPAN1) in esophageal carcinoma (EC) and its association with clinicopathological factors. TSPAN1 small interfering RNA (siRNA) was designed to target the TSPAN1 gene in Eca‑109 cells in order to explore the biological function of TSPAN1 in the proliferation and apoptosis of EC. The results demonstrated that the level of TSPAN1 expression in EC tissue was significantly increased compared with that in adjacent normal tissue (P<0.001). TSPAN1 expression was also associated with histological differentiation, depth of invasion, lymph node metastasis (all P<0.05) and Ki‑67 (P<0.01). However, no association was observed between TSPAN expression and gender, age or location (P>0.05). In addition, silencing TSPAN1 markedly inhibited proliferation while increasing the apoptosis rate of Eca‑109 cells, which was demonstrated by detecting the expression of the cell proliferation‑associated gene Ki‑67 and the apoptotic gene caspase‑3 (P<0.05). Taken together, these results indicated that TSPAN1 functions as a tumor‑associated gene in EC through promoting cell proliferation and suppressing apoptosis, and siRNA technology may provide an advanced alternative in the development of therapeutics for EC.

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December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
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APA
Gu, T., Chen, W., Chen, L., Wang, G., Li, T., Zhu, Y., & Gao, X. (2017). Expression and function of tetraspanin 1 in esophageal carcinoma. Oncology Letters, 14, 6815-6822. https://doi.org/10.3892/ol.2017.7028
MLA
Gu, T., Chen, W., Chen, L., Wang, G., Li, T., Zhu, Y., Gao, X."Expression and function of tetraspanin 1 in esophageal carcinoma". Oncology Letters 14.6 (2017): 6815-6822.
Chicago
Gu, T., Chen, W., Chen, L., Wang, G., Li, T., Zhu, Y., Gao, X."Expression and function of tetraspanin 1 in esophageal carcinoma". Oncology Letters 14, no. 6 (2017): 6815-6822. https://doi.org/10.3892/ol.2017.7028