Prevalence of HPV infection among HIV‑positive and HIV‑negative women in Central/Eastern Italy: Strategies of prevention

  • Authors:
    • Edoardo Tartaglia
    • Katia Falasca
    • Jacopo Vecchiet
    • Giovanna Paola Sabusco
    • Giovanna Picciano
    • Roberto Di Marco
    • Claudio Ucciferri
  • View Affiliations

  • Published online on: October 5, 2017     https://doi.org/10.3892/ol.2017.7140
  • Pages:7629-7635
Metrics: PDF 0 views | HTML 0 views
0

Abstract

The present cross‑sectional‑study aimed to determine the prevalence of human papillomavirus (HPV)‑genotypes among human immunodeficiency virus (HIV)‑positive and ‑negative women in Central/Eastern Italy, and to identify the optimal strategies for effective HPV‑prevention in each group. A representative sample of HIV‑negative (150/200) and ‑positive (50/200) women, who underwent cervico‑vaginal‑swabbing. Swabs were analysed for a cytological screening and for a HPV‑DNA‑genotyping‑test. A total of 66/200 swabs resulted HPV‑positive. The overall HPV‑prevalence was 33% with a higher prevalence in the HIV‑positive‑group (48%) compared with the HIV‑negative‑group (28%). The most frequent genotypes were: 16, 31, 52, 58, 66, 73 and 89. Furthermore, the prevalence of specific genotypes was different in each group. The results of the present study indicate that HIV infection appears to be an independent risk factor for HPV‑infection. In addition, HPV‑infection is more common and more likely to persist in HIV‑positive compared with in HIV‑negative women. The optimal way to counteract HPV infection is through primary prevention. The stage of immunity (cluster of differentiation 4‑level) at the time of the HPV‑screening is one of the most important parameters for detection of susceptibility to HPV‑infection and to evaluate the response to the HPV‑vaccine in HIV‑positive women. It may be used to determine the sub‑group of HIV‑positive women that are more prone to HPV‑infections or that exhibit a partial response to the HPV‑vaccine. At present, a novel type of vaccine with 9‑genotypes is available and in the near future, it may serve an essential role in the prevention of HPV infections.

Related Articles

Journal Cover

December 2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

2016 Impact Factor: 1.39
Ranked #68/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Tartaglia, E., Falasca, K., Vecchiet, J., Sabusco, G.P., Picciano, G., Di Marco, R., & Ucciferri, C. (2017). Prevalence of HPV infection among HIV‑positive and HIV‑negative women in Central/Eastern Italy: Strategies of prevention. Oncology Letters, 14, 7629-7635. https://doi.org/10.3892/ol.2017.7140
MLA
Tartaglia, E., Falasca, K., Vecchiet, J., Sabusco, G. P., Picciano, G., Di Marco, R., Ucciferri, C."Prevalence of HPV infection among HIV‑positive and HIV‑negative women in Central/Eastern Italy: Strategies of prevention". Oncology Letters 14.6 (2017): 7629-7635.
Chicago
Tartaglia, E., Falasca, K., Vecchiet, J., Sabusco, G. P., Picciano, G., Di Marco, R., Ucciferri, C."Prevalence of HPV infection among HIV‑positive and HIV‑negative women in Central/Eastern Italy: Strategies of prevention". Oncology Letters 14, no. 6 (2017): 7629-7635. https://doi.org/10.3892/ol.2017.7140