MicroRNA‑378 regulates cell proliferation and migration by repressing RNF31 in pituitary adenoma
- Peng Qiu
- Tong‑Jiang Xu
- Xiang‑Dong Lu
- Wei Yang
- Yu‑Bao Zhang
- Guang‑Ming Xu
Published online on: November 16, 2017
Copyright: © Qiu et al.
This is an open access article distributed under the terms of Creative Commons Attribution License.
MicroRNA-378 (miR-378) is dysregulated in multiple malignancies and is associated with tumor progression. However, the expression and mechanism of miR‑378 in pituitary adenoma (PA) remains to be elucidated. In the present study, the role and mechanism of miR‑378 in PA tumorigenesis and development was investigated. It was revealed that the levels of miR‑378 expression were markedly downregulated in PA tissues. CCK‑8 and wound healing assays revealed that transfection with miR‑378 mimics was able to markedly inhibit the proliferation and migration of GH3 cells. Furthermore, quantitative polymerase chain reaction analysis demonstrated that ring finger protein 31 (RNF31) was upregulated in PA specimens and the levels of RNF31 expression was negatively regulated by miR‑378. In addition, knockdown of RNF31 markedly suppressed cell proliferation and migration in GH3 cells. In conclusion, the present study provides a molecular basis for the function of miR‑378/RNF31 in the progression of human PA, indicating a potential novel target for the treatment of PA.