MicroRNA-122-3p inhibits tumor cell proliferation and induces apoptosis by targeting Forkhead box O in A549 cells

  • Authors:
    • Wen Wang
    • Jinsong Yang
    • Fenglei Yu
    • Wenjie Li
    • Li Wang
    • Haoyu Zou
    • Xia Long
  • View Affiliations

  • Published online on: December 11, 2017     https://doi.org/10.3892/ol.2017.7577
  • Pages: 2695-2699
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Abstract

The imbalance between cell proliferation and apoptosis was implicated to serve key roles in cancer pathogenesis. The characteristics of microRNAs (miRNAs/miRs) have attracted much attention in research focusing on cancer pathogenesis in recent years. miR‑122‑3p has been reported to be associated with a number of disease processes and pathogenesis, including lung cancer. The present study aimed to investigate the association of miR‑122‑3p expression level with cell proliferation and apoptosis in a lung cancer cell line. A549 cells were transfected with miR‑122‑3p to interrupt the expression of miR‑122‑3p. Subsequently, MTT and BrdU assay, and western blot were used to analyze the influence of miR‑122‑3p on lung cancer cell proliferation, cell viability and its underlying mechanism. The present study revealed that, by targeting p27, overexpression of miR‑122‑3p inhibited cell proliferation in lung cancer. Furthermore, the cell apoptosis analysis suggested that overexpression of miR‑122‑3p was able to inhibit cell apoptosis by targeting Forkhead box O. These findings suggest that miR‑122‑3p may be associated with the pathology and progression of lung cancer and be a new therapeutic target for this disease.

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February 2018
Volume 15 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Wang, W., Yang, J., Yu, F., Li, W., Wang, L., Zou, H., & Long, X. (2018). MicroRNA-122-3p inhibits tumor cell proliferation and induces apoptosis by targeting Forkhead box O in A549 cells. Oncology Letters, 15, 2695-2699. https://doi.org/10.3892/ol.2017.7577
MLA
Wang, W., Yang, J., Yu, F., Li, W., Wang, L., Zou, H., Long, X."MicroRNA-122-3p inhibits tumor cell proliferation and induces apoptosis by targeting Forkhead box O in A549 cells". Oncology Letters 15.2 (2018): 2695-2699.
Chicago
Wang, W., Yang, J., Yu, F., Li, W., Wang, L., Zou, H., Long, X."MicroRNA-122-3p inhibits tumor cell proliferation and induces apoptosis by targeting Forkhead box O in A549 cells". Oncology Letters 15, no. 2 (2018): 2695-2699. https://doi.org/10.3892/ol.2017.7577