Open Access

Potential diagnostic value of serum p53 antibody for detecting colorectal cancer: A meta-analysis

  • Authors:
    • Rongqin Meng
    • Yang Wang
    • Liang He
    • Yuanqing He
    • Zedong Du
  • View Affiliations

  • Published online on: February 16, 2018     https://doi.org/10.3892/ol.2018.8070
  • Pages: 5489-5496
  • Copyright: © Meng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Numerous studies have assessed the diagnostic value of serum p53 (s-p53) antibody in patients with colorectal cancer (CRC); however, results remain controversial. The present study aimed to comprehensively and quantitatively summarize the potential diagnostic value of s‑p53 antibody in CRC. The present study utilized databases, including PubMed and EmBase, systematically regarding s‑p53 antibody diagnosis in CRC, accessed on and prior to 31 July 2016. The quality of all the included studies was assessed using quality assessment of studies of diagnostic accuracy (QUADAS). The result of pooled sensitivity, pooled specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were analyzed and compared with overall accuracy measures using diagnostic odds ratios (DORs) and area under the curve (AUC) analysis. Publication bias and heterogeneity were also assessed. A total of 11 trials that enrolled a combined 3,392 participants were included in the meta‑analysis. Approximately 72.73% (8/11) of the included studies were of high quality (QUADAS score >7), and all were retrospective case‑control studies. The pooled sensitivity was 0.19 [95% confidence interval (CI), 0.18‑0.21] and pooled specificity was 0.93 (95% CI, 0.92‑0.94). Results also demonstrated a PLR of 4.56 (95% CI, 3.27‑6.34), NLR of 0.78 (95% CI, 0.71‑0.85) and DOR of 6.70 (95% CI, 4.59‑9.76). The symmetrical summary receiver operating characteristic curve was 0.73. Furthermore, no evidence of publication bias or heterogeneity was observed in the meta‑analysis. Meta‑analysis data indicated that s‑p53 antibody possesses potential diagnostic value for CRC. However, discrimination power was somewhat limited due to the low sensitivity.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
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Spandidos Publications style
Meng R, Wang Y, He L, He Y and Du Z: Potential diagnostic value of serum p53 antibody for detecting colorectal cancer: A meta-analysis. Oncol Lett 15: 5489-5496, 2018
APA
Meng, R., Wang, Y., He, L., He, Y., & Du, Z. (2018). Potential diagnostic value of serum p53 antibody for detecting colorectal cancer: A meta-analysis. Oncology Letters, 15, 5489-5496. https://doi.org/10.3892/ol.2018.8070
MLA
Meng, R., Wang, Y., He, L., He, Y., Du, Z."Potential diagnostic value of serum p53 antibody for detecting colorectal cancer: A meta-analysis". Oncology Letters 15.4 (2018): 5489-5496.
Chicago
Meng, R., Wang, Y., He, L., He, Y., Du, Z."Potential diagnostic value of serum p53 antibody for detecting colorectal cancer: A meta-analysis". Oncology Letters 15, no. 4 (2018): 5489-5496. https://doi.org/10.3892/ol.2018.8070