Open Access

Protective effect of berberine on acute cardiomyopathy associated with doxorubicin treatment

  • Authors:
    • Chen Xiong
    • Yan‑Zhao Wu
    • Yu Zhang
    • Zi‑Xiao Wu
    • Xue‑Yan Chen
    • Ping Jiang
    • Hui‑Cai Guo
    • Ke‑Rang Xie
    • Ke‑Xin Wang
    • Su‑Wen Su
  • View Affiliations

  • Published online on: February 9, 2018     https://doi.org/10.3892/ol.2018.8020
  • Pages: 5721-5729
  • Copyright: © Xiong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Doxorubicin (DOX) is a potent and broad‑spectrum anthracycline chemotherapeutic agent, but dose‑dependent cardiotoxic side effects limit its clinical application. This toxicity is closely associated with the generation of reactive oxygen species (ROS) radical during DOX metabolism. The present study investigated the effects of Berberine (Ber) on DOX‑induced acute cardiac injury in a rat model and analysed its mechanism in cardiomyocytes in vitro. Serum creatine kinase (CK), creatine kinase isoenzyme (CK‑MB) and malondialdehyde (MDA) levels were significantly increased in the DOX group compared with the control group. This increase was accompanied by cardiac histopathological injury and a decrease in cardiomyocyte superoxide dismutase (SOD) and catalase (CAT). CK, CK‑MB and MDA levels decreased and SOD and CAT levels increased in the Ber‑treated group compared to the DOX group. Ber ameliorated the DOX‑induced increase in cytosolic calcium concentration ([Ca2+]i), attenuated mitochondrial Ca2+ overload and restored the DOX‑induced loss of mitochondrial membrane potential in vitro. These results demonstrated that Ber exhibited protective effects against DOX‑induced heart tissue free radical injury, potentially via the inhibition of intracellular Ca2+ elevation and attenuation of mitochondrial dysfunction.
View Figures
View References

Related Articles

Journal Cover

April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xiong C, Wu YZ, Zhang Y, Wu ZX, Chen XY, Jiang P, Guo HC, Xie KR, Wang KX, Su SW, Su SW, et al: Protective effect of berberine on acute cardiomyopathy associated with doxorubicin treatment. Oncol Lett 15: 5721-5729, 2018
APA
Xiong, C., Wu, Y., Zhang, Y., Wu, Z., Chen, X., Jiang, P. ... Su, S. (2018). Protective effect of berberine on acute cardiomyopathy associated with doxorubicin treatment. Oncology Letters, 15, 5721-5729. https://doi.org/10.3892/ol.2018.8020
MLA
Xiong, C., Wu, Y., Zhang, Y., Wu, Z., Chen, X., Jiang, P., Guo, H., Xie, K., Wang, K., Su, S."Protective effect of berberine on acute cardiomyopathy associated with doxorubicin treatment". Oncology Letters 15.4 (2018): 5721-5729.
Chicago
Xiong, C., Wu, Y., Zhang, Y., Wu, Z., Chen, X., Jiang, P., Guo, H., Xie, K., Wang, K., Su, S."Protective effect of berberine on acute cardiomyopathy associated with doxorubicin treatment". Oncology Letters 15, no. 4 (2018): 5721-5729. https://doi.org/10.3892/ol.2018.8020