MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor

  • Authors:
    • Jianqiao Luo
    • Caidan Zhu
    • Hongya Wang
    • Li Yu
    • Jianwei Zhou
  • View Affiliations

  • Published online on: February 12, 2018     https://doi.org/10.3892/ol.2018.8025
  • Pages: 5803-5808
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Abstract

Primary ovarian cancer is the main cause of gynecological cancer‑associated mortality. However, the mechanism behind the spread of ovarian cancer requires elucidation. The present study aimed to investigate the effects of microRNA‑126 (miR‑126) on differentiation and invasion, and its mechanism in primary ovarian cancer. Ovarian cancer SKOV3 cells transfected with LV3‑has‑miR‑126 mimics and LV3‑has‑miR‑126 inhibitor were produced; it was revealedthatLV‑miR‑126 mimics could induce cell cycle arrest at G1 phase, suppress cell invasion through Matrigel‑coated membranes and downregulate the expression of vascular endothelial growth factor (VEGF). Furthermore, LV‑has‑miR‑126 inhibitor‑transfected cells could increase the number of cells in S phase, induce cell invasion and upregulate the expression of VEGF. The present study, to the best of our knowledge, is the first to report that miR‑126 may serve tumor suppressor roles by inducing G1 cell cycle arrest and suppressing invasion in ovarian cancer cells, at least in part by targeting VEGF expression.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Luo J, Zhu C, Wang H, Yu L and Zhou J: MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor. Oncol Lett 15: 5803-5808, 2018
APA
Luo, J., Zhu, C., Wang, H., Yu, L., & Zhou, J. (2018). MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor. Oncology Letters, 15, 5803-5808. https://doi.org/10.3892/ol.2018.8025
MLA
Luo, J., Zhu, C., Wang, H., Yu, L., Zhou, J."MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor". Oncology Letters 15.4 (2018): 5803-5808.
Chicago
Luo, J., Zhu, C., Wang, H., Yu, L., Zhou, J."MicroRNA-126 affects ovarian cancer cell differentiation and invasion by modulating expression of vascular endothelial growth factor". Oncology Letters 15, no. 4 (2018): 5803-5808. https://doi.org/10.3892/ol.2018.8025