TGF‑β1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis
- Authors:
- Yuyi Wang
- Chi Du
- Nan Zhang
- Mei Li
- Yanyang Liu
- Maoyuan Zhao
- Feng Wang
- Feng Luo
-
Affiliations: Department of Medical Oncology, Lung Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China - Published online on: February 14, 2018 https://doi.org/10.3892/ol.2018.8047
- Pages: 5903-5909
This article is mentioned in:
Abstract
Ugurlucan M, Caglar IM, Caglar FN, Ziyade S, Karatepe O, Yildiz Y, Zencirci E, Ugurlucan FG, Arslan AH, Korkmaz S, et al: Aspirin: From a historical perspective. Recent Pat Cardiovasc Drug Discov. 7:71–76. 2012. View Article : Google Scholar : PubMed/NCBI | |
Vane JR, Flower RJ and Botting RM: History of aspirin and its mechanism of action. Stroke. 21 12 Suppl:IV12–IV23. 1990.PubMed/NCBI | |
Wang S, Liu Z, Wang L and Zhang X: NF-kappaB signaling pathway, inflammation and colorectal cancer. Cell Mol Immunol. 6:327–334. 2009. View Article : Google Scholar : PubMed/NCBI | |
Menter DG and Dubois RN: Prostaglandins in cancer cell adhesion, migration, and invasion. Int J Cell Biol. 2012:7234192012. View Article : Google Scholar : PubMed/NCBI | |
Kanaoka S, Yoshida K, Miura N, Sugimura H and Kajimura M: Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening. Gastroenterology. 127:422–427. 2004. View Article : Google Scholar : PubMed/NCBI | |
Fenwick SW, Toogood GJ, Lodge JP and Hull MA: The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancerliver metastases. Gastroenterology. 125:716–729. 2003. View Article : Google Scholar : PubMed/NCBI | |
Krishnan K, Ruffin MT, Normolle D, Shureiqi I, Burney K, Bailey J, Peters-Golden M, Rock CL, Boland CR and Brenner DE: Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancer. Cancer Epidemiol Biomarkers Prev. 10:447–453. 2001.PubMed/NCBI | |
Derynck R and Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signaling. Nature. 425:577–584. 2003. View Article : Google Scholar : PubMed/NCBI | |
Moon CM, Kwon JH, Kim JS, Oh SH, Jin Lee K, Park JJ, Pil Hong S, Cheon JH, Kim TI and Kim WH: Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer. Int J Cancer. 134:519–529. 2014. View Article : Google Scholar : PubMed/NCBI | |
Vaish V, Tanwar L and Sanyal SN: The role of NF-κB and PPARγ in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors. Tumour Biol. 31:427–436. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ishizaki T, Katsumata K, Tsuchida A, Wada T, Mori Y, Hisada M, Kawakita H and Aoki T: Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancercells via the suppression of MMP-9 activity. Int J Mol Med. 17:357–362. 2006.PubMed/NCBI | |
Shureiqi I, Chen D, Lotan R, Yang P, Newman RA, Fischer SM and Lippman SM: 15-Lipoxygenase-1 mediates nonsteroidalanti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. Cancer Res. 60:6846–6850. 2000.PubMed/NCBI | |
Zhou X, Huang SY, Feng JX, Gao YY, Zhao L, Lu J, Huang BQ and Zhang Y: SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells. World J Gastroenterol. 17:4922–4927. 2011. View Article : Google Scholar : PubMed/NCBI | |
Blobe GC, Schiemann WP and Lodish HF: Role of transforming growth factor beta in human disease. N Engl J Med. 342:1350–1358. 2000. View Article : Google Scholar : PubMed/NCBI | |
Govinden R and Bhoola KD: Genealogy, expression, and cellular function of transforming growth factor-beta. Pharmacol Ther. 98:257–265. 2003. View Article : Google Scholar : PubMed/NCBI | |
Sánchez-Capelo A: Dual role for TGF-beta1 in apoptosis. Cytokine Growth Factor Rev. 16:15–34. 2005. View Article : Google Scholar : PubMed/NCBI | |
Pierce DF Jr, Gorska AE, Chytil A, Meise KS, Page DL, Coffey RJ Jr and Moses HL: Mammary tumor suppression by transforming growth factor beta 1 transgene expression. Proc Natl Acad Sci USA. 92:pp. 4254–4258. 1995; View Article : Google Scholar : PubMed/NCBI | |
Chen L, Lu X, Zeng T, Chen Y, Chen Q, Wu W, Yan X, Cai H, Zhang Z, Shao Q and Qin W: Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-β1-Smad4-PAI-1 axis. Oncol Rep. 31:885–893. 2014. View Article : Google Scholar : PubMed/NCBI | |
Elmore S: Apoptosis: A review of programmed death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Jiang M, Li Z, Wang J, Du C, Yanyang L, Yu Y, Wang X, Zhang N, Zhao M, et al: Hypoxia and TGF-β1 lead to endostatin resistance by cooperatively increasing cancer stem cellsin A549 transplantation tumors. Cell Biosci. 5:722015. View Article : Google Scholar : PubMed/NCBI | |
Yue W, Zheng X, Lin Y, Yang CS, Xu Q, Carpizo D, Huang H, DiPaola RS and Tan XL: Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget. 6:21208–21224. 2015. View Article : Google Scholar : PubMed/NCBI | |
Koseki T, Yamato K, Krajewski S, Reed JC, Tsujimoto Y and Nishihara T: Activin A-induced apoptosis is suppressed by BCL-2. FEBS Lett. 376:247–250. 1995. View Article : Google Scholar : PubMed/NCBI | |
Saltzman A, Munro R, Searfoss G, Franks C, Jaye M and Ivashchenko Y: Transforming growth factor-beta-mediated apoptosis in the Ramos B-lymphoma cell line is accompanied by caspase activation and Bcl-XL downregulation. Exp Cell Res. 242:244–254. 1998. View Article : Google Scholar : PubMed/NCBI | |
Fukuchi Y, Kizaki M, Yamato K, Kawamura C, Umezawa A, Hata Ji, Nishihara T and Ikeda Y: Mcl-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cells. Oncogene. 20:704–713. 2001. View Article : Google Scholar : PubMed/NCBI | |
Chen RH and Chang TY: Involvement of caspase family proteases in transforming growth factor-beta-induced apoptosis. Cell Growth Differ. 8:821–827. 1997.PubMed/NCBI | |
Boatright KM and Salvesen GS: Mechanisms of caspase activation. Curr Opin Cell Biol. 15:725–731. 2003. View Article : Google Scholar : PubMed/NCBI | |
Riedl SJ and Shi Y: Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol. 5:897–907. 2004. View Article : Google Scholar : PubMed/NCBI | |
Thornberry NA and Lazebnik Y: Caspases: Enemies within. Science. 281:1312–1316. 1998. View Article : Google Scholar : PubMed/NCBI | |
Alnemri ES: Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases. J Cell Biochem. 64:33–42. 1997. View Article : Google Scholar : PubMed/NCBI | |
Han BH, DeMattos RB, Dugan LL, Kim-Han JS, Brendza RP, Fryer JD, Kierson M, Cirrito J, Quick K, Harmony JA, et al: Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia. Nat Med. 7:338–343. 2001. View Article : Google Scholar : PubMed/NCBI | |
Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science. 267:1456–1462. 1995. View Article : Google Scholar : PubMed/NCBI | |
Kuhn P and Sarkar DK: Ethanol induces apoptotic death of b-Endorphin neurons in the rat Hypothalamus by a TGF-beta 1-dependent mechanism. Alcohol Clin Exp Res. 32:706–714. 2008. View Article : Google Scholar : PubMed/NCBI | |
Jänne PA and Mayer RJ: Chemoprevention of colorectal cancer. N Engl J Med. 342:1960–1968. 2000. View Article : Google Scholar : PubMed/NCBI | |
Algra AM and Rothwell PM: Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 13:518–527. 2012. View Article : Google Scholar : PubMed/NCBI | |
Rothwell PM, Wilson CE, Elwin M, Norrving B, Algra A, Warlow CP and Meade TW: Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomized trials. Lancet. 376:1741–1750. 2010. View Article : Google Scholar : PubMed/NCBI | |
Patrono C and Rocca B: Aspirin: promise and resistance in the new millennium. Arterioscler Thromb Vasc Biol. 28 Suppl:s25–s32. 2008. View Article : Google Scholar : PubMed/NCBI | |
Lai MY, Huang JA, Liang ZH, Jiang HX and Tang GD: Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480. World J Gastroenterol. 14:4227–4233. 2008. View Article : Google Scholar : PubMed/NCBI | |
Bos CL, Kodach LL, van den Brink GR, Diks SH, van Santen MM, Richel DJ, Peppelenbosch MP and Hardwick JC: Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 25:6447–6456. 2006. View Article : Google Scholar : PubMed/NCBI | |
Martin S, Phillips DC, Szekely-Szucs K, Elghazi L, Desmots F and Houghton JA: Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. Cancer Res. 65:11447–11458. 2005. View Article : Google Scholar : PubMed/NCBI | |
Kim KM, Song JJ, An JY, Kwon YT and Lee YJ: Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem. 280:41047–41056. 2005. View Article : Google Scholar : PubMed/NCBI | |
Johnstone RW, Ruefli AA and Lowe SW: Apoptosis: A link between cancer genetics and chemotherapy. Cell. 108:153–164. 2002. View Article : Google Scholar : PubMed/NCBI | |
Chinnaiyan AM and Dixit VM: The cell-death machine. Curr Biol. 6:555–562. 1996. View Article : Google Scholar : PubMed/NCBI | |
Kasibhatla S and Tseng B: Why target apoptosis in cancer treatment? Mol Cancer Ther. 2:573–580. 2003.PubMed/NCBI | |
Makin G: Targeting apoptosis in cancer chemotherapy. Expert Opin Ther Targets. 6:73–84. 2002. View Article : Google Scholar : PubMed/NCBI | |
Marx J: Cancer research. Anti-inflammatories inhibit cancer growth-but how? Science. 291:581–582. 2001.PubMed/NCBI | |
Fujita T, Matsui M, Takaku K, Uetake H, Ichikawa W, Taketo MM and Sugihara K: Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas. Cancer Res. 58:4823–4826. 1998.PubMed/NCBI | |
Marnett LJ: Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res. 52:5575–5589. 1992.PubMed/NCBI | |
Hanif R, Pittas A, Feng Y, Koutsos MI, Qiao L, Staiano-Coico L, Shiff SI and Rigas B: Effects of nonsteroidal anti-inflammatory drugs onproliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem Pharmacol. 52:237–245. 1996. View Article : Google Scholar : PubMed/NCBI | |
Thun MJ, Jacobs EJ and Patrono C: The role of aspirin in cancer prevention. Nat Rev Clin Oncol. 9:259–267. 2012. View Article : Google Scholar : PubMed/NCBI | |
Sun Y, Chen J and Rigas B: Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death. Carcinogenesis. 30:93–100. 2009. View Article : Google Scholar : PubMed/NCBI | |
Shtivelband MI, Juneja HS, Lee S and Wu KK: Aspirin and salicylate inhibit colon cancer medium- and VEGF-induced endothelial tube formation: Correlation with suppression of cyclooxygenase-2 expression. J ThrombHaemost. 1:2225–2233. 2003. View Article : Google Scholar | |
Tian Y, Ye Y, Gao W, Chen H, Song T, Wang D, Mao X and Ren C: Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway. Int J Colorectal Dis. 26:13–22. 2011. View Article : Google Scholar : PubMed/NCBI | |
Pathi S, Jutooru I, Chadalapaka G, Nair V, Lee SO and Safe S: Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. PLoS One. 7:e482082012. View Article : Google Scholar : PubMed/NCBI | |
Shureiqi I, Xu X, Chen D, Lotan R, Morris JS, Fischer SM and Lippman SM: Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. Cancer Res. 61:4879–4884. 2001.PubMed/NCBI | |
Zhang Z and DuBois RN: Par-4, a proapoptoticgene, is regulated by NSAIDs in human colon carcinoma cells. Gastroenterol. 118:1012–1017. 2000. View Article : Google Scholar | |
Bellosillo B, Piqué M, Barragán M, Castaño E, Villamor N, Colomer D, Montserrat E, Pons G and Gil J: Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukaemia cells. Blood. 92:1406–1414. 1998.PubMed/NCBI | |
Schwenger P, Bellosta P, Vietor I, Basilico C, Skolnik Y and Vilcek J: Sodium salicylate induces apoptosis via p38 mitogen activated protein kinase but inhibits tumour necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation. Proc Natl Acad Sci USA. 94:pp. 2869–2873. 1997; View Article : Google Scholar : PubMed/NCBI | |
Chan TA, Morin PJ, Vogelstein B and Kinzler KW: Mechanisms underlying non-steroidal anti-inflammatory drug-mediated apoptosis. Proc Natl Acad Sci USA. 95:pp. 681–686. 1998; View Article : Google Scholar : PubMed/NCBI | |
Zimmermann KC, Waterhouse NJ, Goldstein JC, Schuler M and Green DR: Aspirin induces apoptosis through release of cytochrome c from mitochondria. Neoplasia. 2:505–513. 2000. View Article : Google Scholar : PubMed/NCBI | |
Din FV, Valanciute A, Houde VP, Zibrova D, Green KA, Sakamoto K, Alessi DR and Dunlop G: Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology. 142:1504–1515.e3. 2012. View Article : Google Scholar : PubMed/NCBI | |
Takada Y, Bhardwaj A, Potdar P and Aggarwal BB: Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 23:9247–9258. 2004. View Article : Google Scholar : PubMed/NCBI | |
Tozawa K, Sakurada S, Kohri K and Okamoto T: Effects of anti-nuclear factor kappa B reagents in blocking adhesion of human cancer cells to vascular endothelial cells. Cancer Res. 55:4162–4167. 1995.PubMed/NCBI | |
Fujioka S, Sclabas GM, Schmidt C, Frederick WA, Dong QG, Abbruzzese JL, Evans DB, Baker C and Chiao PJ: Function of nuclear factor kappaB in pancreatic cancer metastasis. Clin Cancer Res. 9:346–354. 2003.PubMed/NCBI | |
Lu L, Sun HC, Zhang W, Chai ZT, Zhu XD, Kong LQ, Wang WQ, Zhang KZ, Zhang YY, Zhang QB, et al: Aspirin minimized the pro-metastasis effect of sorafenib and improved survival by up-regulating HTATIP2 in hepatocellular carcinoma. PLoS One. 8:e650232013. View Article : Google Scholar : PubMed/NCBI | |
Hossain MA, Kim DH, Jang JY, Kang YJ, Yoon JH, Moon JO, Chung HY, Kim GY, Choi YH, Copple BL and Kim ND: Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. Int J Oncol. 40:1636–1642. 2012. View Article : Google Scholar : PubMed/NCBI | |
Smith RD: Evidence for autocrine growth inhibition of rat intestinal epithelial (RIE-1) cells by transforming growth factor type-beta. Biochem Mol Biol Int. 35:1315–1321. 1995.PubMed/NCBI | |
Murray PA, Barrett-Lee P, Travers M, Luqmani Y, Powles T and Coombes RC: The prognostic significance of transforming growth factors in human breast cancer. Br J Cancer. 67:1408–1412. 1993. View Article : Google Scholar : PubMed/NCBI | |
Sun Y, Gao W, Zhao Y, Cao W, Liu Z, Cui G, Tong L, Lei F and Tang B: Visualization and inhibition of mitochondria-nuclear translocation of apoptosis inducing factor by a graphene oxide-DNA nanosensor. Anal Chem. 89:4642–4647. 2017. View Article : Google Scholar : PubMed/NCBI | |
Oussaief L, Hippocrate A, Ramirez V, Rampanou A, Zhang W, Meyers D, Cole P, Khelifa R and Joab I: Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: Contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation. J Biol Chem. 284:23912–23924. 2009. View Article : Google Scholar : PubMed/NCBI |