TGF‑β1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis

  • Authors:
    • Yuyi Wang
    • Chi Du
    • Nan Zhang
    • Mei Li
    • Yanyang Liu
    • Maoyuan Zhao
    • Feng Wang
    • Feng Luo
  • View Affiliations

  • Published online on: February 14, 2018     https://doi.org/10.3892/ol.2018.8047
  • Pages: 5903-5909
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Abstract

Previous studies have demonstrated that aspirin serves an important role in chemoprevention and the suppression of colorectal cancer (CRC); however, the underlying mechanisms for this inhibition by aspirin remain unclear. Aspirin is capable of promoting apoptosis through prostaglandin‑dependent orprostaglandin‑independent signaling pathways. In the prostaglandin‑dependent pathways, inhibition of cyclooxygenase (COX), particularly COX‑2, is the primary mechanism known to be involved in aspirin‑induced CRC suppression. Previous studies have implicated prostaglandin‑independent signaling pathways and certain associated proteins, including SOX7, in aspirin‑induced CRC suppression. In the present study, a newly‑characterized association between aspirin, transforming growth factor (TGF)‑β1 and CRC inhibition was identified. Specifically, aspirin triggers CRC cell apoptosis by inducing the secretion of TGF‑β1, and the increased TGF‑β1 then leads to apoptosis and proliferation inhibition in CRC cells.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang Y, Du C, Zhang N, Li M, Liu Y, Zhao M, Wang F and Luo F: TGF‑β1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis. Oncol Lett 15: 5903-5909, 2018
APA
Wang, Y., Du, C., Zhang, N., Li, M., Liu, Y., Zhao, M. ... Luo, F. (2018). TGF‑β1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis. Oncology Letters, 15, 5903-5909. https://doi.org/10.3892/ol.2018.8047
MLA
Wang, Y., Du, C., Zhang, N., Li, M., Liu, Y., Zhao, M., Wang, F., Luo, F."TGF‑β1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis". Oncology Letters 15.4 (2018): 5903-5909.
Chicago
Wang, Y., Du, C., Zhang, N., Li, M., Liu, Y., Zhao, M., Wang, F., Luo, F."TGF‑β1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis". Oncology Letters 15, no. 4 (2018): 5903-5909. https://doi.org/10.3892/ol.2018.8047