A novel long non‑coding RNATCONS_00001798 is downregulated and predicts survival in patients with non‑small cell lung cancer

  • Authors:
    • Liuwei Gao
    • Hua Zhang
    • Bin Zhang
    • Changli Wang
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  • Published online on: February 16, 2018     https://doi.org/10.3892/ol.2018.8080
  • Pages: 6015-6021
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Abstract

The morbidity and mortality rates of patients with non‑small cell lung cancer (NSCLC) are increasing worldwide. Previous studies have demonstrated that long non‑coding RNAs (lncRNAs) may serve critical roles in oncogenesis and cancer progression. The present study aimed to investigate the expression of lncRNA TCONS_00001798 and the clinicopathological factors and prognosis of patients with NSCLC. Reverse transcription quantitative polymerase chain reaction (RT‑qPCR) was used to measure the expression of TCONS_00001798 in 118 paired NSCLC and adjacent non‑tumor tissues. The association between TCONS_00001798 expression and patient clinicopathological factors and survival rates was subsequently analyzed. The results demonstrated that the expression of TCONS_00001798 was significantly downregulated in NSCLC tissues compared with adjacent non‑tumor tissues (P<0.001). Additionally, the expression of TCONS_00001798 was negatively associated with lymph node metastasis (P<0.001) and an advanced pathological stage (P=0.003). A Kaplan‑Meier analysis demonstrated that decreased TCONS_00001798 expression was significantly associated with shorter overall survival (OS) and disease‑free survival (DFS) rates (each P<0.001). Furthermore, the results of multivariate analyses revealed that TCONS_00001798 expression may serve as an independent predictor for OS and DFS rates (each P=0.001). Therefore, the present study demonstrated that TCONS_00001798 may be involved in the oncogenesis and progression of NSCLC and that TCONS_00001798 may be a potential diagnostic and therapeutic target in patients with NSCLC.
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April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Gao L, Zhang H, Zhang B and Wang C: A novel long non‑coding RNATCONS_00001798 is downregulated and predicts survival in patients with non‑small cell lung cancer. Oncol Lett 15: 6015-6021, 2018
APA
Gao, L., Zhang, H., Zhang, B., & Wang, C. (2018). A novel long non‑coding RNATCONS_00001798 is downregulated and predicts survival in patients with non‑small cell lung cancer. Oncology Letters, 15, 6015-6021. https://doi.org/10.3892/ol.2018.8080
MLA
Gao, L., Zhang, H., Zhang, B., Wang, C."A novel long non‑coding RNATCONS_00001798 is downregulated and predicts survival in patients with non‑small cell lung cancer". Oncology Letters 15.4 (2018): 6015-6021.
Chicago
Gao, L., Zhang, H., Zhang, B., Wang, C."A novel long non‑coding RNATCONS_00001798 is downregulated and predicts survival in patients with non‑small cell lung cancer". Oncology Letters 15, no. 4 (2018): 6015-6021. https://doi.org/10.3892/ol.2018.8080