Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway (Review)

  • Authors:
    • Dengliang Huang
    • Yiting Wang
    • Jiabin Tang
    • Shiwen Luo
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  • Published online on: March 1, 2018     https://doi.org/10.3892/ol.2018.8142
  • Pages: 6077-6086
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Abstract

Highly conserved throughout evolution, the hedgehog (Hh) signalling pathway has been demonstrated to be involved in embryonic development, stem cell maintenance and tissue homeostasis in animals ranging from invertebrates to vertebrates. In the human body, a variety of cancer types are associated with the aberrantly activated Hh signalling pathway. Multiple studies have revealed suppressor of fused (Sufu) as a key negative regulator of this signalling pathway. In vertebrates, Sufu primarily functions as a tumor suppressor factor by interacting with and inhibiting glioma‑associated oncogene homologues (GLIs), which are the terminal transcription factors of the Hh signalling pathway and belong to the Kruppel family of zinc finger proteins; by contrast, the regulation of Sufu itself remains relatively unclear. In the present review article, we focus on the effects of Sufu on the Hh signalling pathway in tumourigenesis and the molecular mechanisms underlying the regulation of GLI by Sufu. In addition, the factors modulating the activity of Sufu at post‑transcriptional levels are also discussed.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Huang D, Wang Y, Tang J and Luo S: Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway (Review). Oncol Lett 15: 6077-6086, 2018
APA
Huang, D., Wang, Y., Tang, J., & Luo, S. (2018). Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway (Review). Oncology Letters, 15, 6077-6086. https://doi.org/10.3892/ol.2018.8142
MLA
Huang, D., Wang, Y., Tang, J., Luo, S."Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway (Review)". Oncology Letters 15.5 (2018): 6077-6086.
Chicago
Huang, D., Wang, Y., Tang, J., Luo, S."Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway (Review)". Oncology Letters 15, no. 5 (2018): 6077-6086. https://doi.org/10.3892/ol.2018.8142