Open Access

The function of Notch1 intracellular domain in the differentiation of gastric cancer

  • Authors:
    • Sunkuan Hu
    • Qiuxiang Chen
    • Tiesu Lin
    • Wandong Hong
    • Wenzhi Wu
    • Ming Wu
    • Xiaojing Du
    • Rong Jin
  • View Affiliations

  • Published online on: February 26, 2018     https://doi.org/10.3892/ol.2018.8118
  • Pages: 6171-6178
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Due to the complex function of the Notch signal pathway in gastric cancer (GC), the association between Notch homolog 1 (Notch1) intracellular domain (NICD) and differentiation of GC remains unknown. The present study aimed to investigate the potential association between NICD and GC differentiation, and demonstrated that poorly differentiated GC expressed increased NICD levels compared with well differentiated GC. A γ‑secretase inhibitor inhibited the growth of AGS cells through downregulating NICD level. Additional data suggested that a COX‑2 inhibitor caused a marked reduction of NICD level in comparison with a control group treated with dimethyl sulfoxide. Combined administration of γ‑secretase and COX‑2 inhibitor produced a marked inhibition of growth in AGS cells, which suggests that patients with poorly differentiated GC may benefit from the blockage of NICD, which potentially serves a role in GC differentiation.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Hu S, Chen Q, Lin T, Hong W, Wu W, Wu M, Du X and Jin R: The function of Notch1 intracellular domain in the differentiation of gastric cancer. Oncol Lett 15: 6171-6178, 2018
APA
Hu, S., Chen, Q., Lin, T., Hong, W., Wu, W., Wu, M. ... Jin, R. (2018). The function of Notch1 intracellular domain in the differentiation of gastric cancer. Oncology Letters, 15, 6171-6178. https://doi.org/10.3892/ol.2018.8118
MLA
Hu, S., Chen, Q., Lin, T., Hong, W., Wu, W., Wu, M., Du, X., Jin, R."The function of Notch1 intracellular domain in the differentiation of gastric cancer". Oncology Letters 15.5 (2018): 6171-6178.
Chicago
Hu, S., Chen, Q., Lin, T., Hong, W., Wu, W., Wu, M., Du, X., Jin, R."The function of Notch1 intracellular domain in the differentiation of gastric cancer". Oncology Letters 15, no. 5 (2018): 6171-6178. https://doi.org/10.3892/ol.2018.8118