Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review

  • Authors:
    • Sojun Hoshimoto
    • Nobuo Hoshi
    • Iwao Ozawa
    • Moriaki Tomikawa
    • Hirofumi Shirakawa
    • Takeshi Fujita
    • Saho Wakamatsu
    • Sayuri Hoshi
    • Kaoru Hirabayashi
    • Shoichi Hishinuma
    • Yoshiro Ogata
  • View Affiliations

  • Published online on: March 1, 2018     https://doi.org/10.3892/ol.2018.8144
  • Pages: 6475-6480
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Abstract

The current study presents the case of a 72-year-old woman with a rapidly enlarged liver metastasis from esophagogastric junction (EGJ) cancer, accompanied by progressive leukocytosis (47,680/µl) and elevated serum granulocyte colony‑stimulating factor (G‑CSF; 779 pg/ml). The patient underwent right hemihepatectomy 26 months after a total gastrectomy. On the seventh post‑operative day the patient's leukocyte count and serum G‑CSF level decreased to 4,280/µl and ≤19.5 pg/ml, respectively. Histologically, the lesion was a well to moderately differentiated adenocarcinoma similar to the primary lesion. Therefore, this tumor was clinically diagnosed as a G‑CSF‑producing liver metastasis from EGJ cancer, although immunohistochemical staining for G‑CSF was negative. A right pulmonary nodule detected simultaneously with the hepatic mass was resected four months following the hepatectomy and was diagnosed as a pulmonary metastasis. The patient's leukocyte count was normal at the time of her initial surgery for EGJ cancer, and her clinical course varied for different metastatic sites. The liver metastasis was accompanied by progressive leukocytosis and elevated serum G‑CSF and demonstrated rapid tumor growth during a six‑month period, whereas the non‑G‑CSF‑producing pulmonary metastasis grew slowly during the same period. In addition 21 reported cases of G‑CSF‑producing upper gastrointestinal tract cancer were reviewed to elucidate the clinicopathological features of this disease.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hoshimoto S, Hoshi N, Ozawa I, Tomikawa M, Shirakawa H, Fujita T, Wakamatsu S, Hoshi S, Hirabayashi K, Hishinuma S, Hishinuma S, et al: Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review. Oncol Lett 15: 6475-6480, 2018
APA
Hoshimoto, S., Hoshi, N., Ozawa, I., Tomikawa, M., Shirakawa, H., Fujita, T. ... Ogata, Y. (2018). Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review. Oncology Letters, 15, 6475-6480. https://doi.org/10.3892/ol.2018.8144
MLA
Hoshimoto, S., Hoshi, N., Ozawa, I., Tomikawa, M., Shirakawa, H., Fujita, T., Wakamatsu, S., Hoshi, S., Hirabayashi, K., Hishinuma, S., Ogata, Y."Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review". Oncology Letters 15.5 (2018): 6475-6480.
Chicago
Hoshimoto, S., Hoshi, N., Ozawa, I., Tomikawa, M., Shirakawa, H., Fujita, T., Wakamatsu, S., Hoshi, S., Hirabayashi, K., Hishinuma, S., Ogata, Y."Rapid progression of a granulocyte colony-stimulating factor-producing liver tumor metastasized from esophagogastric junction cancer: A case report and literature review". Oncology Letters 15, no. 5 (2018): 6475-6480. https://doi.org/10.3892/ol.2018.8144