Upregulated GAPLINC predicts a poor prognosis in bladder cancer patients and promotes tumor proliferation and invasion

  • Authors:
    • Zaosong Zheng
    • Dingjun Zhu
    • Fengjin Zhao
    • Jinli Han
    • Haicheng Chen
    • Yuhong Cai
    • Wenlian Xie
  • View Affiliations

  • Published online on: March 2, 2018     https://doi.org/10.3892/ol.2018.8158
  • Pages: 6770-6776
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Abstract

Previous studies have demonstrated that long noncoding RNAs (lncRNAs) exhibit critical regulatory roles in cancer biology. However, few lncRNAs have been well characterized in bladder cancer. In the previous study, we demonstrated that gastric adenocarcinoma associated, positive CD44 regulator, long intergenic noncoding RNA (GAPLINC) was significantly upregulated in bladder cancer tissues compared with normal tissues in The Cancer Genome Atlas (TCGA) cohort (P=0.039) and a validated cohort of 80 patients with bladder cancer (P=0.021). Statistical analysis revealed that GAPLINC expression level was associated with tumor stage in the validated cohort (P=0.017). Kaplan‑Meier analysis demonstrated that patients in the high GAPLINC expression group had a worse overall survival (P=0.0386), indicating that GAPLINC may be a sensitive prognostic biomarker for patients with bladder cancer. Furthermore, knockdown of GAPLINC inhibited cell proliferation and colony formation, promoted cells cycle arrest at G1 phase and suppressed cells migration and invasion. The findings of the present study suggest that GAPLINC exhibits an oncogenic role in bladder cancer and may be a potential prognostic biomarker and therapeutic target.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zheng Z, Zhu D, Zhao F, Han J, Chen H, Cai Y and Xie W: Upregulated GAPLINC predicts a poor prognosis in bladder cancer patients and promotes tumor proliferation and invasion. Oncol Lett 15: 6770-6776, 2018
APA
Zheng, Z., Zhu, D., Zhao, F., Han, J., Chen, H., Cai, Y., & Xie, W. (2018). Upregulated GAPLINC predicts a poor prognosis in bladder cancer patients and promotes tumor proliferation and invasion. Oncology Letters, 15, 6770-6776. https://doi.org/10.3892/ol.2018.8158
MLA
Zheng, Z., Zhu, D., Zhao, F., Han, J., Chen, H., Cai, Y., Xie, W."Upregulated GAPLINC predicts a poor prognosis in bladder cancer patients and promotes tumor proliferation and invasion". Oncology Letters 15.5 (2018): 6770-6776.
Chicago
Zheng, Z., Zhu, D., Zhao, F., Han, J., Chen, H., Cai, Y., Xie, W."Upregulated GAPLINC predicts a poor prognosis in bladder cancer patients and promotes tumor proliferation and invasion". Oncology Letters 15, no. 5 (2018): 6770-6776. https://doi.org/10.3892/ol.2018.8158