Open Access

Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance

  • Authors:
    • Jingmei Ye
    • Jiani Wang
    • Nana Zhang
    • Yu Liu
    • Li Tan
    • Lihua Xu
  • View Affiliations

  • Published online on: March 7, 2018     https://doi.org/10.3892/ol.2018.8202
  • Pages: 7182-7190
  • Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to investigate the expression of transactivation response RNA‑binding protein (TARBP)1 and its clinical significance in human non‑small‑cell lung cancer (NSCLC). TARBP1 expression at the mRNA level was detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) in 10 NSCLC tissues and paired adjacent normal tissues. TARBP1 protein expression was analyzed in 90 paraffin‑embedded NSCLC tissue samples and paired adjacent normal tissues by immunohistochemistry. Statistical analyses were performed to assess the clinicopathological significance of TARBP1 expression. The expression of TARBP1 mRNA was higher in the 10 NSCLC samples than in the paired adjacent non‑tumor tissues (P=0.0017). In the paraffin‑embedded tissue samples, the expression level of TARBP1 was higher in the cancer tissues than in the adjacent non‑cancerous tissues. TARBP1 expression was detected in 76.67% (69/90) of the NSCLC samples and in 22.22% (20/90) of the adjacent normal lung tissues (P<0.001). The expression of TARBP1 was significantly associated with histological grade (P<0.001), clinical stage (P=0.024) and pathological type (P<0.001), along with a decreased overall survival (OS) rate (P<0.001). On multivariate analysis, the expression of TARBP1 was an independent prognostic factor for hazard ratio (OS, 2.729; 95% confidence interval, 1.471‑5.061; P=0.003). TARBP1 is overexpressed in NSCLC, and the expression of TARBP1 is associated with pathological grade, clinical stage and pathological type. Thus, TARBP1 may be an independent prognostic marker in patients with NSCLC.
View Figures
View References

Related Articles

Journal Cover

May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ye J, Wang J, Zhang N, Liu Y, Tan L and Xu L: Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance. Oncol Lett 15: 7182-7190, 2018
APA
Ye, J., Wang, J., Zhang, N., Liu, Y., Tan, L., & Xu, L. (2018). Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance. Oncology Letters, 15, 7182-7190. https://doi.org/10.3892/ol.2018.8202
MLA
Ye, J., Wang, J., Zhang, N., Liu, Y., Tan, L., Xu, L."Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance". Oncology Letters 15.5 (2018): 7182-7190.
Chicago
Ye, J., Wang, J., Zhang, N., Liu, Y., Tan, L., Xu, L."Expression of TARBP1 protein in human non-small-cell lung cancer and its prognostic significance". Oncology Letters 15, no. 5 (2018): 7182-7190. https://doi.org/10.3892/ol.2018.8202