Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer

  • Authors:
    • Yuxiu Huang
    • Lihong Chen
    • Aqin Guo
  • View Affiliations

  • Published online on: March 7, 2018     https://doi.org/10.3892/ol.2018.8200
  • Pages: 7291-7296
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Abstract

Homeobox C8 (HOXC8) is a transcription factor that has been reported to regulate numerous genes associated with tumor progression. However, its function in cervical cancer (CC) remains to be elucidated. In the present study, the expression level of HOXC8 was examined in CC tissues and cell lines using reverse transcription‑quantitative polymerase chain reaction and western blot analysis. Additionally, CC cell lines were transfected with small interfering RNAs (siRNAs) to downregulate the expression of HOX8 and assess cell proliferation using Cell Counting Kit‑8. The results demonstrated a significantly increased expression of HOXC8 in CC tissues and cell lines compared with non‑tumor tissues, and a normal cervical cell line, respectively. Additionally, the downregulation of HOXC8, which was achieved by siRNA transfection, significantly inhibited the proliferation rate of CC cell lines. Kaplan‑Meier curves demonstrated that the increased expression of HOXC8 was associated with poor prognosis of patients with CC. Additionally, univariate and multivariate analysis revealed that HOXC8 was a significant and independent predictor for overall survival of patients with CC. In conclusion, the results of the present study suggest that HOXC8 may be involved in the progression of CC and may serve as a therapeutic target for CC.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Huang Y, Chen L and Guo A: Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer. Oncol Lett 15: 7291-7296, 2018
APA
Huang, Y., Chen, L., & Guo, A. (2018). Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer. Oncology Letters, 15, 7291-7296. https://doi.org/10.3892/ol.2018.8200
MLA
Huang, Y., Chen, L., Guo, A."Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer". Oncology Letters 15.5 (2018): 7291-7296.
Chicago
Huang, Y., Chen, L., Guo, A."Upregulated expression of HOXC8 is associated with poor prognosis of cervical cancer". Oncology Letters 15, no. 5 (2018): 7291-7296. https://doi.org/10.3892/ol.2018.8200