Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1

  • Authors:
    • Yoshihiro Suzuki
    • Takashi Oshima
    • Kazue Yoshihara
    • Kentaro Sakamaki
    • Toru Aoyama
    • Haruhiko Cho
    • Manabu Shiozawa
    • Takaki Yoshikawa
    • Yasushi Rino
    • Toshio Imada
    • Munetaka Masuda
  • View Affiliations

  • Published online on: March 13, 2018     https://doi.org/10.3892/ol.2018.8248
  • Pages: 7335-7343
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Abstract

The standard treatment for stage II/III gastric cancer is surgical resection followed by adjuvant chemotherapy with fluoropyrimidine anticancer agents, including S‑1. The protein, secreted protein, acidic and cysteine‑rich (SPARC), promotes angiogenesis, and the proliferation and migration of cancer cells. The present study evaluated the significance of expression of the SPARC gene in patients with stage II/III gastric cancer who had undergone surgical resection and adjuvant chemotherapy with S‑1. In the present study, reverse transcription-quantitative polymerase chain reaction was performed in order to quantify mRNA expression levels of SPARC in cancer tissues and adjacent normal mucosa obtained from 134 patients with stage II/III gastric cancer who had undergone surgical resection followed by adjuvant chemotherapy with S‑1. The mRNA expression level of SPARC was significantly higher in cancer tissues than in adjacent normal mucosa (P=0.0012). Additionally, the 5‑year overall survival rate was significantly poorer in patients with high SPARC gene expression than in those with low expression (P<0.0001). Furthermore, multivariate analysis indicated that high SPARC mRNA expression was a significant predictor of poorer survival in patients with stage II/III gastric cancer who had undergone surgical resection and adjuvant chemotherapy with S‑1 (HR, 5.347; P<0.0001). Therefore, high expression of the SPARC gene may be a useful predictor of outcomes in patients with stage II/III gastric cancer, who have received treatment involving surgical resection and adjuvant chemotherapy with S-1.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Suzuki Y, Oshima T, Yoshihara K, Sakamaki K, Aoyama T, Cho H, Shiozawa M, Yoshikawa T, Rino Y, Imada T, Imada T, et al: Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1. Oncol Lett 15: 7335-7343, 2018
APA
Suzuki, Y., Oshima, T., Yoshihara, K., Sakamaki, K., Aoyama, T., Cho, H. ... Masuda, M. (2018). Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1. Oncology Letters, 15, 7335-7343. https://doi.org/10.3892/ol.2018.8248
MLA
Suzuki, Y., Oshima, T., Yoshihara, K., Sakamaki, K., Aoyama, T., Cho, H., Shiozawa, M., Yoshikawa, T., Rino, Y., Imada, T., Masuda, M."Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1". Oncology Letters 15.5 (2018): 7335-7343.
Chicago
Suzuki, Y., Oshima, T., Yoshihara, K., Sakamaki, K., Aoyama, T., Cho, H., Shiozawa, M., Yoshikawa, T., Rino, Y., Imada, T., Masuda, M."Clinical significance of secreted protein, acidic and cysteine-rich gene expression in patients with stage II/III gastric cancer following curative resection and adjuvant chemotherapy with S-1". Oncology Letters 15, no. 5 (2018): 7335-7343. https://doi.org/10.3892/ol.2018.8248