Open Access

Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO

  • Authors:
    • Shasha Hou
    • Jian Tan
    • Bing Yang
    • Lu He
    • Yu Zhu
  • View Affiliations

  • Published online on: March 26, 2018     https://doi.org/10.3892/ol.2018.8356
  • Pages: 7889-7899
  • Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Thyroid cancer is a common primary tumor in China. Therefore, it is important to investigate the underlying molecular mechanism of thyroid cancer in order to achieve effective individualized treatments. In our previous study, a positive correlation between the expression of alkylglycerone phosphate synthase (AGPS) and the malignant phenotype of thyroid cancer cell lines was identified. The inactivation of AGPS was able to decrease the malignancy of cancer, and inhibit tumor growth and invasion. However, the function of AGPS on thyroid cancer was unclear. In the present study, it was revealed that AGPS was able to regulate the expression of circular RNAs (circRNAs), which may be the mechanism of its anticancer activity. Therefore, the effects of AGPS silencing and knockout on circRNA expression in the thyroid cancer cell line FRO were investigated using circRNAs microarray, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed in order to investigate the underlying molecular mechanism of AGPS for the regulation of thyroid cancer through circRNAs.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Hou S, Tan J, Yang B, He L and Zhu Y: Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. Oncol Lett 15: 7889-7899, 2018
APA
Hou, S., Tan, J., Yang, B., He, L., & Zhu, Y. (2018). Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO. Oncology Letters, 15, 7889-7899. https://doi.org/10.3892/ol.2018.8356
MLA
Hou, S., Tan, J., Yang, B., He, L., Zhu, Y."Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO". Oncology Letters 15.5 (2018): 7889-7899.
Chicago
Hou, S., Tan, J., Yang, B., He, L., Zhu, Y."Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO". Oncology Letters 15, no. 5 (2018): 7889-7899. https://doi.org/10.3892/ol.2018.8356