Downregulation of microRNA‑142‑3p and its tumor suppressor role in gastric cancer

  • Authors:
    • Yi Wang
    • Zhidong Cao
    • Lanlan Wang
    • Siqi Liu
    • Jianqiang Cai
  • View Affiliations

  • Published online on: March 23, 2018     https://doi.org/10.3892/ol.2018.8330
  • Pages: 8172-8180
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Abstract

An increasing number of studies indicate that microRNAs (miRNAs) may exert an oncogenic or tumor suppressive role in diverse types of cancer. MicroRNA (miR)‑142‑3p has been detected to be downregulated in a number of cancer types, and it may function as a tumor suppressor. However, the expression profile and potential role of miR‑142‑3p in gastric cancer remain unknown. In the present study, the expression of miR‑142‑3p in numerous gastric cancer samples was investigated. It was observed that miR‑142‑3p was markedly downregulated in cancer tissues compared with normal tissues. Furthermore, a low expression level of miR‑142‑3p was associated with higher tumor stages. The overexpression of miR‑142‑3p was able to inhibit the proliferation, invasion and migration of gastric cancer cells. A further investigation into the mechanism underlying the effect of miR‑142‑3p identified cyclin T2 (CCNT2) as a target of miR‑142‑3p in gastric cancers. miR‑142‑3p may exert its tumor suppressor role partially by downregulating CCNT2. These results suggested that the abnormal downregulation of miR‑142‑3p and the subsequent increase in CCNT2 expression may have an important role in gastric cancer carcinogenesis.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Cao Z, Wang L, Liu S and Cai J: Downregulation of microRNA‑142‑3p and its tumor suppressor role in gastric cancer. Oncol Lett 15: 8172-8180, 2018
APA
Wang, Y., Cao, Z., Wang, L., Liu, S., & Cai, J. (2018). Downregulation of microRNA‑142‑3p and its tumor suppressor role in gastric cancer. Oncology Letters, 15, 8172-8180. https://doi.org/10.3892/ol.2018.8330
MLA
Wang, Y., Cao, Z., Wang, L., Liu, S., Cai, J."Downregulation of microRNA‑142‑3p and its tumor suppressor role in gastric cancer". Oncology Letters 15.5 (2018): 8172-8180.
Chicago
Wang, Y., Cao, Z., Wang, L., Liu, S., Cai, J."Downregulation of microRNA‑142‑3p and its tumor suppressor role in gastric cancer". Oncology Letters 15, no. 5 (2018): 8172-8180. https://doi.org/10.3892/ol.2018.8330