Open Access

Expression of long‑chain fatty acid receptor GPR40 is associated with cancer progression in colorectal cancer: A retrospective study

  • Authors:
    • Chie Nakashima
    • Kishi Shingo
    • Rina Fujiwara‑Tani
    • Yi Luo
    • Isao Kawahara
    • Kei Goto
    • Takamitsu Sasaki
    • Kiyomu Fujii
    • Hitoshi Ohmori
    • Hiroki Kuniyasu
  • View Affiliations

  • Published online on: March 29, 2018     https://doi.org/10.3892/ol.2018.8383
  • Pages: 8641-8646
  • Copyright: © Nakashima et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

An increased risk of colorectal cancer (CRC) is associated with a western style diet, particularly hyperlipidemia. The expression of G‑protein coupled receptor 40 (GPR40), a membrane‑bound receptor for long‑chain fatty acids (LCFAs), was examined in 36 cases of subserosal‑invading CRC and compared with clinicopathological parameters as well as triglyceride (TG) and low‑density lipoprotein (LDL) levels in the blood. All patients with CRC expressed GPR40, which was positively associated with blood TG levels (P<0.0001) but not with blood LDL levels. GPR40 expression was positively associated with nodal metastasis, distant metastasis (particularly to the liver), stage and poor prognosis. Patients with high GPR40 expression and high TG levels had comparatively worse survival outcomes compared with patients with low GPR40 expression and low TG levels. The results of the present study suggest that activation of GPR40 may be associated with the progression and prognosis of CRCs. High levels of GPR40 and/or concurrent high levels of GPR40 and TG may be a risk for CRC progression.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Nakashima C, Shingo K, Fujiwara‑Tani R, Luo Y, Kawahara I, Goto K, Sasaki T, Fujii K, Ohmori H, Kuniyasu H, Kuniyasu H, et al: Expression of long‑chain fatty acid receptor GPR40 is associated with cancer progression in colorectal cancer: A retrospective study. Oncol Lett 15: 8641-8646, 2018
APA
Nakashima, C., Shingo, K., Fujiwara‑Tani, R., Luo, Y., Kawahara, I., Goto, K. ... Kuniyasu, H. (2018). Expression of long‑chain fatty acid receptor GPR40 is associated with cancer progression in colorectal cancer: A retrospective study. Oncology Letters, 15, 8641-8646. https://doi.org/10.3892/ol.2018.8383
MLA
Nakashima, C., Shingo, K., Fujiwara‑Tani, R., Luo, Y., Kawahara, I., Goto, K., Sasaki, T., Fujii, K., Ohmori, H., Kuniyasu, H."Expression of long‑chain fatty acid receptor GPR40 is associated with cancer progression in colorectal cancer: A retrospective study". Oncology Letters 15.6 (2018): 8641-8646.
Chicago
Nakashima, C., Shingo, K., Fujiwara‑Tani, R., Luo, Y., Kawahara, I., Goto, K., Sasaki, T., Fujii, K., Ohmori, H., Kuniyasu, H."Expression of long‑chain fatty acid receptor GPR40 is associated with cancer progression in colorectal cancer: A retrospective study". Oncology Letters 15, no. 6 (2018): 8641-8646. https://doi.org/10.3892/ol.2018.8383