Open Access

Comprehensive analysis of differentially expressed profiles of lncRNAs and mRNAs reveals ceRNA networks in the transformation of diffuse large B‑cell lymphoma

  • Authors:
    • Lu Tian
    • Yangyan He
    • Hongkun Zhang
    • Ziheng Wu
    • Donglin Li
    • Chengfei Zheng
  • View Affiliations

  • Published online on: May 16, 2018     https://doi.org/10.3892/ol.2018.8722
  • Pages: 882-890
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diffuse large B‑cell lymphoma (DLBCL) is one of the malignancies with a high mortality rate. The molecular mechanisms involved in transformation of DLBCL remain unclear. Therefore, it is critically important to investigate the biological mechanisms of DLBCL. Accumulating evidence indicates that long non‑coding RNAs (lncRNAs) serve key functions in tumorigenesis, cancer progression and metastasis. Compared with follicular lymphoma (FL), a total of 123 upregulated lncRNAs and 192 downregulated lncRNAs in DLBCL were identified. Subsequently, a specific DLBCL‑associated competing endogenous RNA (ceRNA) network and a specific FL‑associated ceRNA network was constructed. Gene Oncology and Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that differentially expressed lncRNAs served key functions in regulating signal transduction, transcription, cell adhesion, development and protein amino acid phosphorylation. Furthermore, the molecular functions of PRKCQ antisense RNA 1, HLA complex P5, OIP5 antisense RNA 1, growth arrest specific 5 and taurine upregulated 1 were investigated, and it was revealed that these lncRNAs served important functions in regulating a series of biological processes, including anti‑apoptosis, cell cycle, DNA repair, response to oxidative stress and transcription. The present study may provide a potential novel therapeutic and prognostic target for the treatment of DLBCL.
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July-2018
Volume 16 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tian L, He Y, Zhang H, Wu Z, Li D and Zheng C: Comprehensive analysis of differentially expressed profiles of lncRNAs and mRNAs reveals ceRNA networks in the transformation of diffuse large B‑cell lymphoma. Oncol Lett 16: 882-890, 2018
APA
Tian, L., He, Y., Zhang, H., Wu, Z., Li, D., & Zheng, C. (2018). Comprehensive analysis of differentially expressed profiles of lncRNAs and mRNAs reveals ceRNA networks in the transformation of diffuse large B‑cell lymphoma. Oncology Letters, 16, 882-890. https://doi.org/10.3892/ol.2018.8722
MLA
Tian, L., He, Y., Zhang, H., Wu, Z., Li, D., Zheng, C."Comprehensive analysis of differentially expressed profiles of lncRNAs and mRNAs reveals ceRNA networks in the transformation of diffuse large B‑cell lymphoma". Oncology Letters 16.1 (2018): 882-890.
Chicago
Tian, L., He, Y., Zhang, H., Wu, Z., Li, D., Zheng, C."Comprehensive analysis of differentially expressed profiles of lncRNAs and mRNAs reveals ceRNA networks in the transformation of diffuse large B‑cell lymphoma". Oncology Letters 16, no. 1 (2018): 882-890. https://doi.org/10.3892/ol.2018.8722