Impact of hemodialysis on the prognosis of multiple myeloma: A nationwide population‑based study and single‑institute analysis

  • Authors:
    • Chao‑Feng Chang
    • Wu‑Chien Chien
    • Chi‑Hsiang Chung
    • Jih‑Chin Lee
    • Shun‑Neng Hsu
    • Jia‑Hong Chen
  • View Affiliations

  • Published online on: May 31, 2018     https://doi.org/10.3892/ol.2018.8857
  • Pages: 1991-2002
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Abstract

Myeloma‑associated kidney disease (MRKD) occurs in ≤40% patients with multiple myeloma (MM). The impact of hemodialysis (HD) on patients with MM was investigated. Between 2000 and 2010, a total of 1,610 patients in Taiwan were enrolled from the National Health Institute Research Database. MM was an independent risk factor for HD following adjustment via multivariate logistic regression analysis (adjusted hazard ratio, 7.347; 95% confidence interval, 6.156‑8.768; log‑rank test, P<0.001). In addition, a notable decrease in survival rate was determined in patients with MM who underwent HD in the first year since diagnosis of MM. A total of 198 (61.49%) patients received HD in the first year. Patients with MM with a lower frequency of HD in the first year had a relatively good prognosis. The present study confirmed that MM was a risk factor for HD. Significant early mortality in the first year was determined in patients with MM who underwent HD; however, renal recovery following therapeutic management was a prognostic factor. In addition to anti‑myeloma therapy, early initiation of HD was beneficial following risk stratification of MRKD; however, an increased probability of recovery of renal function and discontinuation of dialysis, was demonstrated in patients with MM following HD, compared with patients with MM without HD.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chang CF, Chien WC, Chung CH, Lee JC, Hsu SN and Chen JH: Impact of hemodialysis on the prognosis of multiple myeloma: A nationwide population‑based study and single‑institute analysis. Oncol Lett 16: 1991-2002, 2018
APA
Chang, C., Chien, W., Chung, C., Lee, J., Hsu, S., & Chen, J. (2018). Impact of hemodialysis on the prognosis of multiple myeloma: A nationwide population‑based study and single‑institute analysis. Oncology Letters, 16, 1991-2002. https://doi.org/10.3892/ol.2018.8857
MLA
Chang, C., Chien, W., Chung, C., Lee, J., Hsu, S., Chen, J."Impact of hemodialysis on the prognosis of multiple myeloma: A nationwide population‑based study and single‑institute analysis". Oncology Letters 16.2 (2018): 1991-2002.
Chicago
Chang, C., Chien, W., Chung, C., Lee, J., Hsu, S., Chen, J."Impact of hemodialysis on the prognosis of multiple myeloma: A nationwide population‑based study and single‑institute analysis". Oncology Letters 16, no. 2 (2018): 1991-2002. https://doi.org/10.3892/ol.2018.8857