Use of Clavien‑Dindo classification in evaluating complications following pancreaticoduodenectomy in 1,056 cases: A retrospective analysis from one single institution

  • Authors:
    • Wei‑Guo Wang
    • Shah Ram Babu
    • Li Wang
    • Yang Chen
    • Bo‑Le Tian
    • Hong‑Bo He
  • View Affiliations

  • Published online on: May 24, 2018     https://doi.org/10.3892/ol.2018.8798
  • Pages: 2023-2029
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Abstract

The Clavien‑Dindo (C‑D) classification is a simple and feasible grading system of postoperative complications. The aim of the present study was to apply this system to retrospectively classify all types of post‑pancreaticoduodenectomy (PD) complications (PPCs) and to systematically identify associated risk factors. Between January 2009 and December 2014, the C‑D classification was applied to retrospectively classify PPCs for 1,056 patients who had undergone PD at the West China Hospital. Univariate and multivariate analyses were performed to link perioperative parameters and mortality with the severity of PPCs, which were subdivided into overall PPCs (Grade I‑V), severe PPCs (Grade III‑V) and mortality (Grade V). The number of patients with Clavien‑Dindo grade I, II, IIIa, IIIb, IVa, IVb and V complications was 185 (17.5%), 128 (12.1%), 50 (4.7%), 25 (2.4%), 35 (3.3%), 19 (1.8%) and 33 (3.1%), respectively. A total of 475 (45.0%) patients experienced overall PPCs; 168 (15.9%) patients experienced severe PPCs; and 33 patients succumbed to mortality following PD. The following risk factors were identified following PD: Preoperative hypoproteinemia was correlated with all three subdivisions; obstructive jaundice was associated with severe PPCs and mortality; and older age was revealed to be an independent risk factor of mortality. A large retrospective study was performed in the present study and PD was correlated with a high occurrence of PPCs. The Clavien‑Dindo system represents a broad applicable and feasible approach to evaluating PPCs in patients following PD. The independent risk factors of PPCs that were identified in the present study require further validation using the Clavien‑Dindo classification in additional prospective studies.

Introduction

Pancreatoduodenectomy (PD) is the main surgical option for pancreatic neoplasms, duodenal neoplasms and other lesions located in the pancreatic head and periampullary region (1). Despite the prompt progress in surgical technologies and the persistent innovation of postoperative treatments over the last decades, post-pancreaticoduodenectomy complications (PPC) remain around 30–60% (24), which may lead to several potential poor outcomes, including prolonged hospital stays, increased medical costs and mortality, all of which also affect pancreatic surgeons and researchers. Therefore, assessing outcomes and quality of PD has triggered interest in measuring and evaluating PPCs.

In most previous studies, various definitions and classifications were applied to access specific PPCs. For example, the International Study Group of Pancreatic Surgery (ISGPS) have formulated a series of generally acceptable, objective definitions and classifications for postoperative pancreatic fistula (POPF), post-pancreatectomy hemorrhage (PPH), and delayed gastric emptying (DGE) following PD from 2005 in order to facilitate objective and accurate comparison among different surgical experiences and diverse associated studies (57). These classifications have been widely used and favored by numerous studies (3,8,9). However, there are a number of limitations to these classifications: i) They are only focused on specific PPCs, including PPH, POPF and DGE; ii) each system has complicated and unique assessment criteria for only one type of PPC and therefore, one type of classification is not applicable to others; and iii) synergistic efforts and risk factors cannot assessed among these diverse classifications (10,11).

Owing to a lack of uniform classification, it is difficult and unfeasible to uniformly interpret various PPCs. In 1992, Pierre Alain Clavien et al (12) established the Clavien-Dindo (C-D) classification, a simple and feasible grading system for all types of postoperative complications. The C-D classification system is characterized by a consistent therapy-oriented, 4-level severity grading, discriminating overall PPCs, and has been increasingly applied to evaluate surgical practices (10,13,14). However, to the best of our knowledge, this grading system has not been used to evaluate PPCs in a large-sample cohort. Therefore, the present study applied this system to retrospectively classify all PPCs and systematically identify associated risk factors in our high-volume pancreatic center.

Patients and methods

Patients

All patients who underwent PD at West China Hospital (Sichuan, China) between January 2009 and December 2014 were included, comprising 660 males (62.5%) and 396 females (37.5%) with a mean age of 57.29±10.99 (range, 18–88) years. All related data, including the patient characteristics, histopathology, surgical factors, postoperative treatments and outcomes, were collected from our database records and the electronic medical records of individual patients.

Operative technique

Each surgical team performed either open PD or laparoscopic PD in >20 cases annually according to the standards of the National Comprehensive Cancer Network (15). As the standard requirement of PD, the following organs were removed in the resection stage: Pylorus, distal antrum of the stomach, duodenum, pancreatic head, distal common bile duct, gallbladder and part of the jejunum. Vessel reconstruction was performed in patients who were investigated for segment or circumferential involvement of the superior mesenteric/portal vein or short segment extension to the superior mesenteric artery. Multivisceral resections were performed in patients who were investigated for adjacent organ invasion, including colon, liver, small bowel, spleen and kidney. In the reconstruction stage, pancreatic remnant was uniformly reconstructed by pancreatojejunostomy over an internal pancreatic stent or external pancreatic drainage according to the preference of the surgeon. Either classical Child type or isolated Roux-en-Y type of reconstruction was selected according to patient features during surgery.

Perioperative interventions and treatments

Preoperative evaluation of general condition was assessed by preoperative routine chest X-ray, electrocardiogram, laboratory tests and respiratory function tests. All patients routinely received perioperative antibiotic (Cefoxitin 1 g, Cefmetazole 1 g or Cefuroxime 1 g; intravenous drip) prophylaxis 1 h prior to surgery and every 3 h during surgery. Routine biochemical blood tests were measured every 2–3 days after surgery, or more often in the presence of PPCs. Ultrasonography or computed tomography scans were performed every 1–2 weeks according to postoperative features. As POPF is considered to be a common PPC, pancreatic amylase activity of abdominal drainage secretions was routinely investigated every 2–3 days from the third postoperative day (POD). Patients also underwent preventative postoperative somatostatin injection (Stilamin, Merck Serono Corp.; 12 mg/day) if they had complication-associated factors, including advanced age, diabetes and soft pancreatic remnant.

Complications

The inpatient and outpatient medical records for each included patient were reviewed to identify various PPCs from the standard recovery, including the following local complications: POPF, PPH, intra-abdominal infection, incision complication, DGE, biliary fistula, intestinal obstruction, intestinal fistula, chylous fistula and acute pancreatitis; and the following systemic complications: Pulmonary complication, sepsis, cardiac complication and deep venous thrombosis.

PPH and POPF were defined according to the ISGPS criterion (4,7). DGE was defined according to the Johns Hopkins definitions (16). Rare complications were defined as those with an incidence of <1% of all the included patients. All complications were defined according to the Clavien-Dindo classification (12). Mortality was defined as any patients who succumbed over a 60-day hospital stay, regardless of cause. These were graded into overall complications (Grade I–V), severe complications (Grade III–V) and mortality (Grade V) based on the PPC-related intervention (e.g., medical treatment or an invasive intervention) or mortality.

Statistical analysis

Table I presents the descriptive statistics of basic characteristics and surgical details. Table II presents the inter-grade differences of each PPPC which were compared with rare complications using the Ridit test. Table III presents univariate analysis of risk factors of all C-D classification. Normally distributed variables are reported as the mean and standard deviation and compared using Student's t-tests. Non-normally distributed variables are expressed as the median (range) and were compared by Mann-Whitney U-tests. Categorical data were compared using χ2 test, with Yates continuity correction in a two-way contingency table, or Fisher's exact test. Additionally, Table IV presents multivariate analysis, which included the potential factors with P≤0.05 in univariate analysis. And it was analyzed by binary logistic regression with conditional backward selection of potential factors. The results of the multivariate logistic regression analysis are expressed using P-values, odds ratios (ORs) and 95% confidence intervals (CIs). All statistical analyses were performed using IBM SPSS Version 22 (IBM Corp., Armonk, NY, USA). P≤0.05 was considered to indicate a statistically significant difference.

Table I.

Demographic characteristics, and pathological and surgical details of all patients.

Table I.

Demographic characteristics, and pathological and surgical details of all patients.

VariableValue
Total1,056 (100)
Sex
  Male660 (62.5)
  Female396 (37.5)
Age, years57.29±10.99
Preoperative factors
  Smoking380 (35.4)
  Diabetes223 (21.1)
  Alcohol abuse167 (15.6)
  Chronic pancreatitis127 (12.0)
  Total bilirubin, mmol/l125.00±122.09
  Hemoglobin, g/l121.50±20.29
  Serum albumin, g/l38.19±5.43
  CA19-9, U/l247.65±327.40
  Preoperative biliary drainage122 (11.6)
ASA grade
  I593 (56.2)
  II318 (30.1)
  III145 (13.7)
Histopathology
  Pancreatic ductal adenocarcinoma347 (32.9)
  Periampullary adenocarcinoma522 (49.4)
  Chronic pancreatitis45 (4.3)
  Other pancreatic neoplasms91 (8.6)
  Other51 (4.8)
Pancreas texture
  Soft548 (51.9)
  Firm508 (48.1)
Tumor size, cm3.31±1.77
Size of pancreatic duct, mm
  ≤3347 (32.9)
  <3709 (67.1)
Intraoperative transfusions1.56±18.51
Intraoperative transfused patients319 (29.7)
Total transfusions3.49±22.79
Laparoscopic PD40 (3.8)
Vessel reconstruction105 (9.9)
Multivisceral resection44 (4.2)
  Colon13 (1.2)
  Spleen4 (0.4)
  Liver11 (1.1)
  Small bowel9 (0.9)
  Kidney8 (0.8)
Postoperative hospital stay, days16.22±10.87

[i] Data are presented as n (%) or as the mean ± standard deviation. CA19-9, cancer antigen 19-9; ASA, American Society of Anesthesiologists; PD, pancreaticoduodenectomy.

Table II.

Characteristics of Clavien-Dindo classification of all post-pancreaticoduodenectomy complications.

Table II.

Characteristics of Clavien-Dindo classification of all post-pancreaticoduodenectomy complications.

TotalGrade IGrade IIGrade IIIaGrade IIIbGrade IVaGrade IVbGrade V








ComplicationsN%N%N%N%N%N%N%N%P-value
Total47545.018517.512812.1504.7252.4353.3191.8333.1
POPF26425.014354.24617.43011.472.7176.4103.8114.20.000
Intra-abdominal infection888.366.82730.72730.733.41213.689.155.70.000
Incision complication878.23641.41314.91314.91011.51011.544.611.10.000
Pulmonary complication938.811.13133.31010.833.21819.41415.11617.20.000
PPH787.400.01417.91417.91215.41515.467.71721.80.000
Delayed gastric emptying302.813.32376.726.700.013.326.713.30.021
Sepsis262.500.0415.400.000.0519.2519.21246.20.004
Renal complication222.100.029.100.014.500.0313.61672.70.014
Heart complication151.4213.3533.300.000.0213.3533.316.70.317
Biliary fistula90.9444.4333.3222.200.000.000.000.01.000
Intestinal obstruction90.900.0222.200.0555.6111.100.0111.10.690
Chylous fistula70.7457.1228.6114.300.000.000.000.00.831
Deep venous thrombosis50.500.0240.000.000.0120.000.0240.00.925
Intestinal fistula20.200.0150.0150.000.000.000.000.00.609
Acute pancreatitis20.200.0150.0150.000.000.000.000.00.609

[i] PPH, postpancreatectomy hemorrhage; POPF, postoperative pancreatic fistula.

Table III.

Univariate analysis of risk factors in the Clavien-Dindo classification.

Table III.

Univariate analysis of risk factors in the Clavien-Dindo classification.

Overall complication (Grade I–V)Severe complication (Grade III–V)Mortality (Grade V)



Univariate analysisValueP-valueValueP-valueValueP-value
Total475 (45.0) 168 (15.9) 33 (3.1)
Age, years 0.129 0.035 0.000
  <75449 (94.5) 155 (92.3) 26 (78.8)
  ≥7526 (5.5) 13 (7.7) 7 (21.2)
Sex 0.848 0.139 0.856
  Male295 (62.1) 114 (67.9) 20 (60.6)
  Female180 (37.9) 54 (32.1) 13 (39.4)
Diabetes99 (20.8)0.88023 (13.7)0.0107 (21.2)1.000
Chronic pancreatitis45 (9.5)0.02215 (8.9)0.1973 (9.1)0.598
Total bilirubin, mmol/l123.66±130.030.102160.29±142.480.008173.40±119.130.019
Serum albumin, g/l34.90±5.490.04834.43±5.320.03433.06±4.880.019
Hemoglobin, g/l121.11±21.000.056120.20±21.130.001114.64±18.860.004
CA19-9, U/l238.90±327.390.055302.32±363.100.097373.28±393.790.469
Preoperative biliary drainage58 (12.2)0.56312 (7.1)0.6403 (9.1)0.653
Laparoscopic PD26 (5.5)0.0148 (6.4)0.5071 (3.0)0.817
Intraoperative transfusions1.31±3.360.0011.81±5.100.0011.76±2.310.038
Vessel reconstruction43 (9.1)0.40914 (8.3)0.5734 (12.1)0.671
Total multivisceral resection23 (4.8)0.35510 (6.0)0.2083 (9.1)0.150

[i] CA19-9, cancer antigen 19-9; PD, pancreaticoduodenectomy.

Table IV.

Multivariate analysis of characteristics in the Clavien-Dindo classification.

Table IV.

Multivariate analysis of characteristics in the Clavien-Dindo classification.

95% confidence interval

CharacteristicP-valueOdds ratioLowerUpper
Overall complications (Grade I–V)
  Serum albumin, g/l0.0161.4751.0731.978
  Cancer antigen 19-9, U/l0.0550.7450.5771.063
  Hemoglobin, g/l0.0530.7620.5791.003
  Intraoperative transfusions0.0670.6110.2251.119
Severe complications (Grade III–V)
  Serum albumin, g/l0.0091.6231.1302.332
  Total bilirubin, mmol/l0.0481.4431.0042.073
  Intraoperative transfusions0.0520.5260.7201.677
Mortality (Grade V)
  Age ≥75 years0.0005.8602.32114.979
  Serum albumin, g/l0.0342.1911.0634.516
  Total bilirubin, mmol/l0.0422.0171.8494.789

Results

Patient characteristics and surgical details

All basic patient characteristics and surgical details are summarized in Table I. Patient preoperative conditions included the following: 380 (35.4%) smokers, 223 (21.1%) with diabetes, 167 (15.6%) with alcohol abuse and 127 (12.1%) with chronic pancreatitis. A total of 122 (11.6%) patients underwent preoperative biliary drainage. According to the pathological observations, periampullary adenocarcinoma was identified as the major subtype (522 patients, 49.4%), followed by pancreatic ductal adenocarcinoma with 32.9% (347 patients).

The majority of patients underwent open PD (1,016 patients, 96.2%) and 40 (3.8%) patients underwent laparoscopic PD. During surgery, 319 (29.7%) patients were transfused with 1.56±18.52 units of blood on average. There were 105 (9.9%) vessel reconstructions and 44 (4.2%) multivisceral resections, which included colon (13 cases, 1.2%), liver (11 cases, 1.0%), small bowel (9 cases, 0.9%), spleen (4 cases, 0.4%) and kidney (8 cases, 0.8%). The mean postoperative hospital stay of all patients was 16.22±10.87 days. Pancreatic texture, tumor size, size of pancreatic duct and details of transfusion are presented in Table I.

Postoperative complications

Of all the included patients, 475 (45.0%) developed complications. Over time, the incidence of complications gradually decreased from 47.4% in 2009 to 44.0% in 2014. All postoperative complications are summarized in Table II. POPF, a major complication, occurred in 264 (25.0%) patients. Pulmonary complications, which occurred in 93 (8.8%) patients, were identified as the major systemic complication. There were 6 types of complication with rare incidences (<1% of the included patients), including biliary fistula, intestinal obstruction, chylous fistula, deep venous thrombosis, intestinal fistula and acute pancreatitis.

According to the C-D classification, all patients with complications were identified as having the following grades of disease: 185 (17.5%), grade I; 128 (12.1%), grade II; 50 (4.7%), grade IIIa; 25 (2.4%), grade IIIb; 35 (3.3%), grade IVa; 19 (1.8%), grade IVb; and 33 (3.1%), grade V. Compared with biliary fistula (incidence, <1% of all the included patients), the C-D classification identified the differences in severity, and the differences between disease grades as being significant (P<0.05, Table II). With regards to disease grades, patients with grade II or higher disease, excluding grade V disease, which resulted in patient mortality, had significantly longer postoperative hospital stays than those with grade 0 or I disease (P<0.05; Fig. 1).

Risk factors for complications

Univariate and multivariate analyses of risk factors for PPCs were divided into three parts according to the severity of the C-D grade: Overall complications (Grade I–V), severe complications (Grade III–V) and mortality (Grade V; Tables III and IV).

The results of univariate analyses are presented in Table III. The overall complications (Grade I–V) were significantly associated with chronic pancreatitis (P=0.022), serum albumin (P=0.048), laparoscopic PD (P=0.014) and intraoperative transfusions (P=0.001). Severe complications (Grade III–V) were revealed to be associated with an age ≥75 years (P=0.035), diabetes (P=0.010), total bilirubin (P=0.008), serum albumin (P=0.034), hemoglobin (P=0.001) and intraoperative transfusions (P=0.001). Mortality (Grade V), was associated with an age ≥75 years (P<0.001), total bilirubin (P=0.019), serum albumin (P=0.019), hemoglobin (P=0.004) and intraoperative transfusions (P=0.038).

Table IV demonstrates the results of multivariate analyses. In terms of overall complications (Grade I–V), the incidence was proven to be associated with lower preoperative serum albumin (P=0.016; OR, 1.475; 95% CI, 1.073–1.978). Severe complications (Grade III–V) were revealed to be associated with lower serum albumin (P=0.009; OR, 1.623; 95% CI, 1.130–2.332) and higher total bilirubin (P=0.048; OR, 1.443; 95% CI, 1.004–2.073). With regards to mortality (Grade V), an age ≥75 years (P=0.000; OR, 5.860; 95% CI, 2.321–14.979), lower serum albumin (P=0.034; OR, 2.191; 95% CI, 1.063–4.516) and higher total bilirubin (P=0.042; OR, 2.017; 95% CI, 1.849–4.789) were identified as independent risk factors.

Discussion

The present large sample cohort study was conducted to retrospectively analyze PPCs at West China Hospital. The C-D grading consistently classifies all types of PPCs with uniform and feasible criteria, whether postoperative therapy is required and which type of therapy is applied. Furthermore, these criteria have been applied to evaluate postoperative complications in a number of different surgical fields (1719). Therefore, its advantage is to respectively systematically analyze all risk factors associated with PPCs and to affect the final outcomes of PD. In the present study, certain independent risk factors were confirmed on the basis of the PPC-related intervention.

Due to the fact that serum albumin is produced in the liver and normally forms ~50% of human plasma protein with unique functions of oncotic pressure maintaining, transportation and inflammatory reaction. Hypoproteinemia, a very common condition in preoperative laboratory tests of PD, has been identified as a reliable indicator of the nutritional status of a patient (20). However, this is easily ignored by pancreatic surgeons, particularly modest hypoproteinemia (serum albumin ≤30 and ≤35 mg/l). In the present study, preoperative hypoproteinemia was correlated with PPCs, which was supported by a previous American retrospective study in 108,898 patients who underwent colorectal surgery (21). The latter study evaluated the association between modest hypoproteinemia and postoperative morbidity, and revealed that patients with preoperative hypoproteinemia exhibited a higher incidence of hospitalization for >30 days, unplanned intubation and wound disruption (21). Clinically, postoperative administration of human albumin is routinely infused to patients with hypoproteinemia following major abdominal surgery. However, persistent consumption, postoperative fasting, surgical trauma and development of PPCs occlude the extravascular deficiency of serum albumin and worsen the nutritional status of the patient. Therefore, preoperative hypoproteinemia requires consideration and necessary treatments to be administered, which means not only raising the preoperative serum albumin level, but also comprehensively improving the preoperative nutritional status of the patients in order to improve their surgical recovery.

Owing to cholestasis from biliary obstruction, obstructive jaundice is a common clinical manifestation for diseases at the pancreatic head and periampullary region. Cholestasis also causes endotoxemia, impairs immune responses and suppresses intravascular coagulation of blood cells, which was believed to worsen the early outcomes of patients following pancreatic surgery (22). These conclusions were also supported by the results of the present study, which demonstrated that jaundice increased the incidences of severe complications (grade III–V) and mortality (grade V) following PD. However, the outcomes of PD were not proven to benefit from preoperative biliary drainage, a common palliative intervention for jaundice, in the present study. This inconsistent correlation was also reported by a multicenter prospective randomized study in 202 patients with pancreatic cancer (23). It was explained that routine preoperative biliary drainage is associated with a relatively high incidence of technical failure and technical complications, particularly drainage occlusion and cholangitis (23). Therefore, routine preoperative biliary drainage does not benefit patients with obstructive jaundice who will undergo surgery (23,24). In addition, the exact mechanisms by which jaundice increases PPCs and the value of preoperative biliary drainage require validation in additional studies (25).

With the gradually increasing number of older patients being considered for PD, the correlation between advanced age and PPCs has received attention from patients and surgeons. The results of the present study demonstrated that older patients (age, ≥75 years) exhibited a higher rate of mortality. However, this result requires confirmation. Older patients were reported to have similar morbidity and mortality rates than younger patients by an American retrospective study in 727 patients undergoing PD (26). By contrast, another study enrolled 3,736 patients to determine age-dependent short-term outcomes following pancreatic resection by bivariate and multivariate analyses (27). Older patients exhibited a significantly higher in-hospital mortality rate than younger patients (11.4 vs. 2.4%). They are also more likely to require care at an inpatient nursing or acute care facility at the time of discharge. Therefore, this result reminds pancreatic surgeons to cautiously recommend PD for older patients and to pay more attention to older patients with PPCs.

There are certain limitations to the present study. To begin with, long-term outcomes of pancreaticoduodenectomy were not evaluated in the present study. Additionally, the results of the present study were limited by the inherent defects of retrospective analysis, including information bias and selection bias. In the present study, however, all types of PPCs were evaluated as the uniform C-D classification. Univariate and multivariate analyses were performed in order to obtain reliable results. However, a further large-scaled, prospective study is required to evaluate the results of the present study and to obtain more valuable results.

A large retrospective study was performed in the present study and PD is correlated with a high occurrence of PPCs. The Clavien-Dindo system represents a widely applicable and feasible system for evaluating PPCs in patients following PD. The independent risk factors of PPCs that were identified in the present study require further validation using the Clavien-Dindo classification in further prospective studies.

Acknowledgements

Not applicable.

Funding

The present study was supported by the scientific research fund of the Science and Technology Department of Chengdu (grant no. 2014-HM01-00290-SF).

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Authors' contributions

BLT designed the present study, YC and WGW conducted the majority of the experimentation, SRB and LW collected the data and edited the manuscript, WGW and YC analyzed data, and WGW drafted the manuscript. BLT and HBH interpreted the results and offered intellectual contribution to the manuscript.

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wang WG, Babu SR, Wang L, Chen Y, Tian BL and He HB: Use of Clavien‑Dindo classification in evaluating complications following pancreaticoduodenectomy in 1,056 cases: A retrospective analysis from one single institution. Oncol Lett 16: 2023-2029, 2018
APA
Wang, W., Babu, S.R., Wang, L., Chen, Y., Tian, B., & He, H. (2018). Use of Clavien‑Dindo classification in evaluating complications following pancreaticoduodenectomy in 1,056 cases: A retrospective analysis from one single institution. Oncology Letters, 16, 2023-2029. https://doi.org/10.3892/ol.2018.8798
MLA
Wang, W., Babu, S. R., Wang, L., Chen, Y., Tian, B., He, H."Use of Clavien‑Dindo classification in evaluating complications following pancreaticoduodenectomy in 1,056 cases: A retrospective analysis from one single institution". Oncology Letters 16.2 (2018): 2023-2029.
Chicago
Wang, W., Babu, S. R., Wang, L., Chen, Y., Tian, B., He, H."Use of Clavien‑Dindo classification in evaluating complications following pancreaticoduodenectomy in 1,056 cases: A retrospective analysis from one single institution". Oncology Letters 16, no. 2 (2018): 2023-2029. https://doi.org/10.3892/ol.2018.8798