The impact of inflammation and cytokine expression of PM2.5 in AML

  • Authors:
    • Tingting Chen
    • Juan Zhang
    • Hui Zeng
    • Yue Zhang
    • Yong Zhang
    • Xiaohuan Zhou
    • Dong Zhao
    • Yingmei Feng
    • Hebing Zhou
  • View Affiliations

  • Published online on: June 13, 2018     https://doi.org/10.3892/ol.2018.8965
  • Pages: 2732-2740
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Abstract

Environmental and health issues have become a major focus of research worldwide in recent years. Particulate matter with diameter ≤2.5 µm (PM2.5) is a common air pollutant that has been demonstrated to be associated with various diseases, including acute myeloid leukemia (AML). In the present study, the effects of PM2.5 on the proliferation and inflammation were assessed using three human acute myeloid cell lines (U937, HL‑60 and KG‑1a) in vitro. Additionally, the levels of several cytokines [interleukin (IL)‑2, IL‑10, IL‑17A and tumor necrosis factor (TNF)α] in AML cells and Sprague Dawley rats were evaluated to investigate the effects of PM2.5 on cytokine expression in AML. The results revealed that PM2.5 was capable of enhancing inflammatory responses in AML cells, and increasing IL‑2, IL‑10, IL‑17A and TNFα mRNA expression in AML cells to different degrees. Furthermore, PM2.5 increased IL‑2 and IL‑10 contents in rats following 12 weeks of exposure. These results suggested that PM2.5 may serve a role in promoting the occurrence and progression of leukemia by affecting cytokine expression, and that there may be various mechanisms active in different AML subtypes.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen T, Zhang J, Zeng H, Zhang Y, Zhang Y, Zhou X, Zhao D, Feng Y and Zhou H: The impact of inflammation and cytokine expression of PM2.5 in AML. Oncol Lett 16: 2732-2740, 2018
APA
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X. ... Zhou, H. (2018). The impact of inflammation and cytokine expression of PM2.5 in AML. Oncology Letters, 16, 2732-2740. https://doi.org/10.3892/ol.2018.8965
MLA
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., Zhao, D., Feng, Y., Zhou, H."The impact of inflammation and cytokine expression of PM2.5 in AML". Oncology Letters 16.2 (2018): 2732-2740.
Chicago
Chen, T., Zhang, J., Zeng, H., Zhang, Y., Zhang, Y., Zhou, X., Zhao, D., Feng, Y., Zhou, H."The impact of inflammation and cytokine expression of PM2.5 in AML". Oncology Letters 16, no. 2 (2018): 2732-2740. https://doi.org/10.3892/ol.2018.8965