Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells

  • Authors:
    • Tian Li
    • Kewei Xu
    • Yifan Liu
  • View Affiliations

  • Published online on: June 18, 2018     https://doi.org/10.3892/ol.2018.8982
  • Pages: 3162-3168
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Abstract

Salidroside has a wide range of pharmacological activities, including antitumor, anti‑inflammatory, analgesic, antibacterial, antiviral and anti‑fertility abilities. In the present study, the effects of salidroside on the viability and apoptosis of bladder cancer cells, and the potential underlying mechanisms, were examined. In the present study, treatment with salidroside reduced cell viability, and induced apoptosis and caspase‑9/3 activation in the T24 human bladder carcinoma cell line. Salidroside induced autophagy, promoted the protein expression of nucleoporin p62 and the microtubule‑associated proteins 1A/1B light chain 3B, suppressed phosphoinositide 3‑kinase (PI3K) and phosphorylated protein kinase B (p‑Akt) expression, inhibited matrix metalloproteinase‑9 (MMP‑9) expression and increased that of Bcl‑2‑associated X protein, which functions as an apoptosis regulator in T24 cells. In the present study, it was demonstrated that the effect of salidroside reduced the viability and induced the apoptosis of bladder cancer cells through the autophagy/PI3K/Akt and MMP‑9 signaling pathways.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li T, Xu K and Liu Y: Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells. Oncol Lett 16: 3162-3168, 2018
APA
Li, T., Xu, K., & Liu, Y. (2018). Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells. Oncology Letters, 16, 3162-3168. https://doi.org/10.3892/ol.2018.8982
MLA
Li, T., Xu, K., Liu, Y."Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells". Oncology Letters 16.3 (2018): 3162-3168.
Chicago
Li, T., Xu, K., Liu, Y."Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells". Oncology Letters 16, no. 3 (2018): 3162-3168. https://doi.org/10.3892/ol.2018.8982