MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88

  • Authors:
    • Fan Zhang
    • Yanjie Zhu
    • Guoxin Fan
    • Shuo Hu
  • View Affiliations

  • Published online on: June 27, 2018     https://doi.org/10.3892/ol.2018.9029
  • Pages: 3359-3364
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Abstract

Osteosarcoma is the most common primary bone malignancy in children and young adults. It is associated with dysregulation of certain microRNAs (miRNAs/miRs), which provides a target for osteosarcoma therapy. miR‑2682‑3p expression in osteosarcoma cell lines and tissues was assayed by reverse transcription‑quantitative polymerase chain reaction and was upregulated or downregulated by transfection with miRNA mimics or inhibitors. miR‑2682‑3p was downregulated in osteosarcoma tissues and cell lines, and overexpression of miR‑2682‑3p inhibited tumor growth. Further studies revealed that cyclin D1 (CCND)2, matrix metalloproteinase (MMP)8, and myeloid differentiation primary response (Myd)88 were the direct targets of miR‑2682‑3p in osteosarcoma cells. Overexpression of miR‑2682‑3p promoted osteosarcoma cell apoptosis by targeting CCND2, MMP8, and Myd88, and vice‑versa. Therefore, miR‑2682‑3p may act as a tumor suppressor gene, the downregulation of which contributed to the progression and metastasis of osteosarcoma, to provide a potential therapy target for patients with osteosarcoma.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang F, Zhu Y, Fan G and Hu S: MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88. Oncol Lett 16: 3359-3364, 2018
APA
Zhang, F., Zhu, Y., Fan, G., & Hu, S. (2018). MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88. Oncology Letters, 16, 3359-3364. https://doi.org/10.3892/ol.2018.9029
MLA
Zhang, F., Zhu, Y., Fan, G., Hu, S."MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88". Oncology Letters 16.3 (2018): 3359-3364.
Chicago
Zhang, F., Zhu, Y., Fan, G., Hu, S."MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88". Oncology Letters 16, no. 3 (2018): 3359-3364. https://doi.org/10.3892/ol.2018.9029