AZD8055 inhibits ACTH secretion in a case of bilateral ACTH‑secreting pheochromocytoma

  • Authors:
    • Fen Wang
    • Anli Tong
    • Chunyan Li
    • Yunying Cui
    • Jian Sun
    • Ailing Song
    • Yuxiu Li
  • View Affiliations

  • Published online on: July 25, 2018     https://doi.org/10.3892/ol.2018.9210
  • Pages: 4561-4566
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Abstract

Ectopic adrenocorticotropic hormone (ACTH) syndrome is usually caused by pulmonary and bronchial tumors and rarely by pheochromocytoma. To date, the majority of ACTH‑secreting pheochromocytomas have been unilateral, with the exception of two cases. A 54‑year‑old male presented with hypertension and bilateral adrenal tumors. The patient did not report having classic cushingoid features or experience of paroxysmal headaches or sweating, but presented with a slight abdominal obesity. The patient was clinically and pathologically diagnosed with bilateral ectopic ACTH‑secreting pheochromocytomas. Whole‑exome sequencing demonstrated that the 19 pheochromocytoma‑related genes were unmutated. The pheochromocytomas on the two sides exhibited negative ACTH staining, but the ACTH concentration was markedly higher in the tumor tissue homogenates than in those tumors of another 3 patients with non‑ACTH secretion pheochromocytoma. Electron microscopy identified two types of neuroendocrine cells in the tumor tissues. Primary culture of the pheochromocytoma cells revealed that ACTH secretion was inhibited by a mechanistic target of rapamycin inhibitor, AZD8055.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang F, Tong A, Li C, Cui Y, Sun J, Song A and Li Y: AZD8055 inhibits ACTH secretion in a case of bilateral ACTH‑secreting pheochromocytoma. Oncol Lett 16: 4561-4566, 2018
APA
Wang, F., Tong, A., Li, C., Cui, Y., Sun, J., Song, A., & Li, Y. (2018). AZD8055 inhibits ACTH secretion in a case of bilateral ACTH‑secreting pheochromocytoma. Oncology Letters, 16, 4561-4566. https://doi.org/10.3892/ol.2018.9210
MLA
Wang, F., Tong, A., Li, C., Cui, Y., Sun, J., Song, A., Li, Y."AZD8055 inhibits ACTH secretion in a case of bilateral ACTH‑secreting pheochromocytoma". Oncology Letters 16.4 (2018): 4561-4566.
Chicago
Wang, F., Tong, A., Li, C., Cui, Y., Sun, J., Song, A., Li, Y."AZD8055 inhibits ACTH secretion in a case of bilateral ACTH‑secreting pheochromocytoma". Oncology Letters 16, no. 4 (2018): 4561-4566. https://doi.org/10.3892/ol.2018.9210