Long non‑coding RNA AB007962 is downregulated in gastric cancer and associated with poor prognosis

  • Authors:
    • Jia‑Jun Wang
    • Yu‑Chong Yang
    • Yong‑Xi Song
    • Peng Gao
    • Jing‑Xu Sun
    • Xiao‑Wan Chen
    • Bin Ma
    • Zhen‑Ning Wang
  • View Affiliations

  • Published online on: July 18, 2018     https://doi.org/10.3892/ol.2018.9169
  • Pages: 4621-4627
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Abstract

A number of previous studies have reported that numerous long non‑coding RNAs (lncRNAs) are dysregulated in gastric cancer (GC) and are involved in a series of biological and pathological processes. Total RNA was extracted from the cancerous tissues and matched normal adjacent tissues (NATs) of 96 patients with GC. The expression level of AB007962, a novel lncRNA, was determined by reverse transcription‑quantitative polymerase chain reaction. The association between AB007962 expression levels and clinicopathological features were analyzed. Kaplan‑Meier curves were also constructed in order to evaluate prognosis. Finally, publicly accessible data from The Cancer Genome Atlas was used to further verify the expression levels and clinical significance of AB007962. In conclusion, it was determined that the expression level of AB007962 was significantly reduced, compared with matched NATs in GC tissues (P=0.003). Survival analysis indicated that patients with intestinal‑type GC with a reduced expression of AB007962 had a reduced prognosis, compared with those with an increased expression. AB007962 may be involved in the progression of GC and act as a novel prognostic biomarker for patients with GC, particularly in intestinal‑type GC.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang JJ, Yang YC, Song YX, Gao P, Sun JX, Chen XW, Ma B and Wang ZN: Long non‑coding RNA AB007962 is downregulated in gastric cancer and associated with poor prognosis. Oncol Lett 16: 4621-4627, 2018
APA
Wang, J., Yang, Y., Song, Y., Gao, P., Sun, J., Chen, X. ... Wang, Z. (2018). Long non‑coding RNA AB007962 is downregulated in gastric cancer and associated with poor prognosis. Oncology Letters, 16, 4621-4627. https://doi.org/10.3892/ol.2018.9169
MLA
Wang, J., Yang, Y., Song, Y., Gao, P., Sun, J., Chen, X., Ma, B., Wang, Z."Long non‑coding RNA AB007962 is downregulated in gastric cancer and associated with poor prognosis". Oncology Letters 16.4 (2018): 4621-4627.
Chicago
Wang, J., Yang, Y., Song, Y., Gao, P., Sun, J., Chen, X., Ma, B., Wang, Z."Long non‑coding RNA AB007962 is downregulated in gastric cancer and associated with poor prognosis". Oncology Letters 16, no. 4 (2018): 4621-4627. https://doi.org/10.3892/ol.2018.9169