Open Access

Interleukin‑15 suppresses gastric cancer liver metastases by enhancing natural killer cell activity in a murine model

  • Authors:
    • Wei Wang
    • Jiejie Jin
    • Faxiang Dai
    • Ziwen Long
    • Xiaowen Liu
    • Hong Cai
    • Ye Zhou
    • Zhong Chen
    • Hua Huang
  • View Affiliations

  • Published online on: August 14, 2018     https://doi.org/10.3892/ol.2018.9303
  • Pages: 4839-4846
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Interleukin (IL)‑15 is a promising cytokine for cancer immunotherapy as it is a critical factor for the proliferation and activation of natural killer (NK) cells. Previous studies have suggested critical roles of IL‑15 in tumor invasion and metastasis. However, the association between IL‑15 and liver metastasis of gastric cancer (LMGC) remains unknown. The present study investigated the therapeutic efficacy of recombinant mouse IL‑15 (rmIL‑15) in murine LMGC models, in which stable green fluorescent protein (GFP)‑expressing MKN45 cells (MKN45‑GFP cells) were injected into the spleen parenchyma of mice for liver metastasis. At different treatments (high dose group: 2.5 µg of rmIL‑15; low dose group: 0.2 µg of rmIL‑15; control group: PBS), it was found that rmIL‑15 decreased the formation of liver metastasis sites. Additionally, this treatment lead to improved survival of mice following tumor cell transplantation. Treatment with a high dose of rmIL‑15 provided greater therapeutic efficacy by prolonged survival of the mice compared with low dose group and control group. It was found that NK cells isolated from the liver that received the high dose of rmIL‑15 showed stronger cytotoxic activity compared with the other two groups on the target cells. These findings hold significant importance for the use of IL‑15 as a potential adjuvant/therapeutic for liver metastasis from gastric cancer.
View Figures
View References

Related Articles

Journal Cover

October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Jin J, Dai F, Long Z, Liu X, Cai H, Zhou Y, Chen Z and Huang H: Interleukin‑15 suppresses gastric cancer liver metastases by enhancing natural killer cell activity in a murine model. Oncol Lett 16: 4839-4846, 2018
APA
Wang, W., Jin, J., Dai, F., Long, Z., Liu, X., Cai, H. ... Huang, H. (2018). Interleukin‑15 suppresses gastric cancer liver metastases by enhancing natural killer cell activity in a murine model. Oncology Letters, 16, 4839-4846. https://doi.org/10.3892/ol.2018.9303
MLA
Wang, W., Jin, J., Dai, F., Long, Z., Liu, X., Cai, H., Zhou, Y., Chen, Z., Huang, H."Interleukin‑15 suppresses gastric cancer liver metastases by enhancing natural killer cell activity in a murine model". Oncology Letters 16.4 (2018): 4839-4846.
Chicago
Wang, W., Jin, J., Dai, F., Long, Z., Liu, X., Cai, H., Zhou, Y., Chen, Z., Huang, H."Interleukin‑15 suppresses gastric cancer liver metastases by enhancing natural killer cell activity in a murine model". Oncology Letters 16, no. 4 (2018): 4839-4846. https://doi.org/10.3892/ol.2018.9303