Urothelial bladder carcinoma metastasizing to the eye: A systematic review and case report

  • Authors:
    • Guido Giordano
    • Nunzio Olivieri
    • Mario Rosario D'Andrea
    • Tania Di Raimo
    • Erminia Manfrin
    • Andrea Remo
    • Massimo Pancione
    • Matteo Brunelli
    • Elena De Santis
    • Giulia Coppola
    • Aldo Scarpa
    • Luigi Coppola
    • Pietro Parcesepe
  • View Affiliations

  • Published online on: October 15, 2018     https://doi.org/10.3892/ol.2018.9579
  • Pages: 462-467
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Abstract

The eye is a rare site for disseminated malignancies; nevertheless, several tumors may metastasize to ocular structures. Few cases of urothelial and bladder cancer with eye involvement have been described in the literature thus far. The rarity of metastatic ocular localization implies an accurate differential diagnosis among the possible primary tumor sites. However, a specific diagnostic algorithm is not currently available, nor a defined therapeutic approach. Eye metastases are associated with advanced disease and poor prognosis. Physicians should be made aware of the possibility of eye involvement in patients with a past medical history of urothelial bladder cancer associated with ocular symptoms. The present case reports discusses the first documented case, to the best of our knowledge, of an urothelial bladder cancer metastasizing to the retro bulbar region that infiltrates the lacrimal gland. Furthermore, the report provides a systematic qualitative review of the current literature on eye metastases from urothelial bladder cancer using the Preferred Reporting Items for Systematic Reviews and Meta‑Analyses.
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January-2019
Volume 17 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Giordano G, Olivieri N, D'Andrea MR, Di Raimo T, Manfrin E, Remo A, Pancione M, Brunelli M, De Santis E, Coppola G, Coppola G, et al: Urothelial bladder carcinoma metastasizing to the eye: A systematic review and case report. Oncol Lett 17: 462-467, 2019
APA
Giordano, G., Olivieri, N., D'Andrea, M.R., Di Raimo, T., Manfrin, E., Remo, A. ... Parcesepe, P. (2019). Urothelial bladder carcinoma metastasizing to the eye: A systematic review and case report. Oncology Letters, 17, 462-467. https://doi.org/10.3892/ol.2018.9579
MLA
Giordano, G., Olivieri, N., D'Andrea, M. R., Di Raimo, T., Manfrin, E., Remo, A., Pancione, M., Brunelli, M., De Santis, E., Coppola, G., Scarpa, A., Coppola, L., Parcesepe, P."Urothelial bladder carcinoma metastasizing to the eye: A systematic review and case report". Oncology Letters 17.1 (2019): 462-467.
Chicago
Giordano, G., Olivieri, N., D'Andrea, M. R., Di Raimo, T., Manfrin, E., Remo, A., Pancione, M., Brunelli, M., De Santis, E., Coppola, G., Scarpa, A., Coppola, L., Parcesepe, P."Urothelial bladder carcinoma metastasizing to the eye: A systematic review and case report". Oncology Letters 17, no. 1 (2019): 462-467. https://doi.org/10.3892/ol.2018.9579